Combining systemic retinoids with biologic agents for moderate to severe psoriasis

International Journal of Dermatology
Elizabeth C A SmithMark G Lebwohl

Abstract

Moderate to severe psoriasis, which is defined as psoriasis affecting more than 20% of the body surface area, often requires a combination of therapies to achieve remission. Although numerous data exist regarding the use of acitretin and biologic agent therapy alone for psoriasis, little is known about the efficacy, safety, and tolerability of acitretin combined with biologic agents. Fifteen patients with psoriasis treated with concomitant acitretin and a biologic agent were identified, and their charts were reviewed for response to therapy, additional therapy necessary for disease management, side-effects, and laboratory abnormalities whilst on combination therapy. The Institutional Review Board did not require approval for this chart review. Twenty-nine per cent of patients showed clearance of psoriasis, 43% of patients showed an improvement of 90%, 14% showed an improvement of 75%, and 7.1% showed no change. During treatment with acitretin and biologic agent, five patients required no adjunctive treatment. Three patients were able to stop narrow-band ultraviolet-B (UV-B) therapy after an average of 2.33 months of combination therapy. Only one patient continued to require phototherapy (UV-B) in addition to the biologic agent....Continue Reading

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Citations

Jan 1, 2009·Clinical, Cosmetic and Investigational Dermatology·Thao U Nguyen, John Koo
Nov 7, 2014·American Journal of Clinical Dermatology·Jennifer C Cather, Jeffrey J Crowley
Jul 31, 2013·Actas dermo-sifiliográficas·G CarreteroUNKNOWN Psoriasis Group of the AEDV
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