Combining Voxel-based Lesion-symptom Mapping (VLSM) With A-tDCS Language Treatment: Predicting Outcome of Recovery in Nonfluent Chronic Aphasia

Brain Stimulation
Serena CampanaPaola Marangolo

Abstract

Most of transcranial direct current stimulation (tDCS) studies in aphasia have already shown that significant changes in language performance could be improved by increased monitoring of the perilesional cortex in the left lesioned hemisphere with excitatory anodal tDCS (A-tDCS). However, no report to date has investigated which areas may be less predictable or may play a major role in the recovery from language impairment after brain stimulation. We investigated the relationship between the localization of damage in the left hemisphere and the amount of language recovery after A-tDCS. We conducted a Voxel-lesion mapping-symptom (VLSM) analysis on twenty non-fluent aphasics who underwent a language treatment in concomitance with left A-tDCS delivered over the left inferior frontal gyrus (IFG) and a sham condition. Significant changes in language performance before and after the two conditions were examined in three language tasks (picture description, noun and verb naming). VLSM analysis revealed that damage to distinct left hemispheric structures and, in particular, to the basal ganglia, the insula and the superior and inferior longitudinal fasciculi, resulted in lower responses to A-tDCS in all language measures. Beneficial e...Continue Reading

References

Apr 13, 1999·Lancet·R J WiseS K Scott
Apr 22, 2003·Nature Neuroscience·Elizabeth BatesNina F Dronkers
Mar 1, 1978·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·E De Renzi, P Faglioni
Feb 22, 2007·Neurorehabilitation and Neural Repair·Paolo VitaliStefano F Cappa
Jun 23, 2007·Journal of Cognitive Neuroscience·Daniel Y KimbergMyrna F Schwartz
Aug 23, 2007·Neuroreport·Fabrizio Piras, Paola Marangolo
Nov 28, 2007·AJNR. American Journal of Neuroradiology·J I BreierA C Papanicolaou
Jul 11, 2008·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Marco Catani, Marsel Mesulam
Oct 28, 2008·NeuroImage·Chris RordenHans-Otto Karnath
Nov 14, 2008·Proceedings of the National Academy of Sciences of the United States of America·Dorothee SaurCornelius Weiller
Jul 21, 2009·Neuroscience Research·Hugues Duffau
Jun 16, 2010·Brain and Language·Elizabeth RochonCheryl Grady
Aug 17, 2010·Current Neurology and Neuroscience Reports·Alfredo Ardila
Sep 3, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Julius Fridriksson
Jul 2, 2011·Stroke; a Journal of Cerebral Circulation·Sarah MarchinaGottfried Schlaug
Jan 10, 2012·NeuroImage·Julius FridrikssonBo Cai
Jan 13, 2012·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Alberto BizziSylvie Piacentini
Apr 10, 2012·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Juliana V BaldoNina F Dronkers
Nov 10, 2012·Journal of Neurology, Neurosurgery, and Psychiatry·Alessia MontiAlberto Priori
Sep 21, 2013·Frontiers in Human Neuroscience·Paola MarangoloAndrea Marini
Sep 21, 2013·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Hugues Duffau
Oct 18, 2013·Brain : a Journal of Neurology·Julius FridrikssonChris Rorden
Dec 7, 2013·Expert Review of Neurotherapeutics·Paola Marangolo, Carlo Caltagirone
Dec 18, 2013·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Anthony Steven DickPascale Tremblay
Apr 2, 2014·Neuropsychologia·Stefanie AbelKlaus Willmes

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Citations

Mar 28, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Mark R EthertonOna Wu
Jun 19, 2018·Brain : a Journal of Neurology·Zoe V J WoodheadJennifer T Crinion
Jul 23, 2015·Stroke; a Journal of Cerebral Circulation·Ona WuNatalia S Rost
Sep 13, 2019·Stroke; a Journal of Cerebral Circulation·Shauna Berube, Argye E Hillis
Jan 28, 2020·Journal of the International Neuropsychological Society : JINS·Elodie GuillouëtSophie Charveriat
May 22, 2020·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Kesshi M JordanRoland G Henry
Apr 21, 2020·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·A V BelopasovaM M Tsypushtanova
Sep 29, 2020·Frontiers in Neurology·Shereen J MatarMarousa Pavlou
Oct 8, 2020·Frontiers in Human Neuroscience·Aya S IharaJun Tanemura
Nov 25, 2020·Expert Review of Neurotherapeutics·Shannon M Sheppard, Rajani Sebastian
Jan 7, 2021·Brain Sciences·Chiara PicanoPaola Marangolo
Nov 27, 2020·Brain Communications·Rajani SebastianArgye E Hillis
Dec 22, 2020·Current Physical Medicine and Rehabilitation Reports·Bonnie L Breining, Rajani Sebastian
May 16, 2020·Brain Stimulation·Marom BiksonHamed Ekhtiari
Mar 30, 2021·Current Physical Medicine and Rehabilitation Reports·Rachel FabianArgye E Hillis
Jul 28, 2020·The International Journal of Neuropsychopharmacology·Felipe FregniUNKNOWN Neuromodulation Center Working Group
Jun 10, 2021·Journal of Stroke·Julius Fridriksson, Argye Elizabeth Hillis

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