Combining Wolbachia-induced sterility and virus protection to fight Aedes albopictus-borne viruses

PLoS Neglected Tropical Diseases
Riccardo MorettiMaurizio Calvitti

Abstract

Among the strategies targeting vector control, the exploitation of the endosymbiont Wolbachia to produce sterile males and/or invasive females with reduced vector competence seems to be promising. A new Aedes albopictus transinfection (ARwP-M) was generated by introducing wMel Wolbachia in the ARwP line which had been established previously by replacing wAlbA and wAlbB Wolbachia with the wPip strain. Various infection and fitness parameters were studied by comparing ARwP-M, ARwP and wild-type (SANG population) Ae. albopictus sharing the same genetic background. Moreover, the vector competence of ARwP-M related to chikungunya, dengue and zika viruses was evaluated in comparison with ARwP. ARwP-M showed a 100% rate of maternal inheritance of wMel and wPip Wolbachia. Survival, female fecundity and egg fertility did not show to differ between the three Ae. albopictus lines. Crosses between ARwP-M males and SANG females were fully unfertile regardless of male age while egg hatch in reverse crosses increased from 0 to about 17% with SANG males aging from 3 to 17 days. When competing with SANG males for SANG females, ARwP-M males induced a level of sterility significantly higher than that expected for an equal mating competitiveness (...Continue Reading

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Citations

Sep 10, 2020·Annual Review of Microbiology·E P CaragataG Dimopoulos
Jun 26, 2020·Frontiers in Microbiology·Mariana MateosGeorge Tsiamis
Sep 11, 2019·Annual Review of Genetics·Perran A RossAry A Hoffmann
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Jul 26, 2021·Trends in Parasitology·Eric P CaragataLuciano A Moreira
Nov 14, 2021·Parasites & Vectors·Maria G OnyangoAlexander T Ciota

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Datasets Mentioned

BETA
AM258992
EU482591
KX197192
AF020064.1

Methods Mentioned

BETA
transinfection
PCR

Software Mentioned

PASW Statistics
PASW
AR

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