Combretum lanceolatum extract reverses anxiety and seizure behavior in adult zebrafish through GABAergic neurotransmission: an in vivo and in silico study.

Journal of Biomolecular Structure & Dynamics
Antônio Wlisses da SilvaEmmanuel Silva Marinho

Abstract

Combretaceae are reported in the literature for presenting neuroprotective and anxiolytic effects in animal models. Combretum lanceolatum Pohl. has few scientific reports on its pharmacological effects. The aim of this study was to evaluate the anxiolytic and anticonvulsant effects of the ethanol extract from the leaves of C. lanceolatum Pohl. (EtFoCl) and its possible mechanism of GABAergic action in adult zebrafish. EtFoCl was subjected to determination of the total phenol concentration, identification of phytochemical flavonoids by HPLC and in vitro antioxidant activity test, open field test and 96-hour acute toxicity in zebrafish. Anxiolytic doses were tested for pentylenetetrazole-induced seizures in adult zebrafish. To study the mechanisms of action, molecular docking simulations were performed between the main phytochemicals and the GABAA receptor (anxiolytic activity) and carbonic anhydrase II (anticonvulsant). The non-toxic doses that caused motor impairment were assessed in acute and chronic anxiety using the light and dark test. EtFoCl had altered the animals' locomotion, presenting an effect similar to the anxiolytic and anticonvulsant. These effects were prevented with flumazenil (GABAA antagonist). The phytochemic...Continue Reading

References

Jul 21, 2004·Journal of Computational Chemistry·Eric F PettersenThomas E Ferrin
Jul 5, 2008·Journal of Chemical Information and Modeling·Dilmurat YusufStefan Schmitt
Sep 2, 2008·Neuropharmacology·Richard W Olsen, Werner Sieghart
Feb 12, 2009·Journal of the American Chemical Society·Alfonso MarescaClaudiu T Supuran
Feb 6, 2010·Nature Protocols·Caio MaximinoSilvio Morato
Jan 18, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Caio MaximinoAnderson Manoel Herculano
May 17, 2011·Pharmacology, Biochemistry, and Behavior·Daiane L GebauerDiogo R Lara
Aug 4, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gedson Rodrigues de Morais LimaLeônia Maria Batista
Aug 15, 2012·Journal of Cheminformatics·Marcus D HanwellGeoffrey R Hutchison
Jan 22, 2013·Expert Opinion on Drug Metabolism & Toxicology·Alfredo Carlo AltamuraSilvio Bareggi
Oct 2, 2013·Indian Journal of Pharmaceutical Sciences·M F ShaikhS Sathaye
Nov 29, 2013·Proceedings. Biological Sciences·Trevor James HamiltonMartin Tresguerres
Sep 13, 2014·Advances and Applications in Bioinformatics and Chemistry : AABC·Sergey Shityakov, Carola Förster
Jan 7, 2015·Zebrafish·Anna Maria SiebelCarla Denise Bonan
Feb 6, 2015·Oxidative Medicine and Cellular Longevity·Tâmara Coimbra DinizJackson Roberto Guedes da Silva Almeida
Jul 15, 2015·BMC Complementary and Alternative Medicine·Bianca A Torres-HernándezJosé G Ortíz
Sep 1, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·Steven TranRobert Gerlai
Feb 13, 2016·Pharmaceutical Biology·Juliany Torres SiqueiraAmanda Martins Baviera
Feb 22, 2017·British Journal of Pharmacology·Kanza M KhanDavid J Echevarria
Jun 13, 2017·Progress in Neuro-psychopharmacology & Biological Psychiatry·Talise Ellwanger MüllerDenis Broock Rosemberg
Jul 14, 2017·Zebrafish·Francisco Ernani Alves MagalhãesAdriana Rolim Campos
Dec 2, 2017·Pharmacology & Therapeutics·Mohammed AkbarAntonio Noronha
Jan 24, 2018·Progress in Neuro-psychopharmacology & Biological Psychiatry·Hifsa ZahidRobert Gerlai
Mar 24, 2018·Journal of Food and Drug Analysis·Cara WelchQingli Wu
Jan 4, 2019·Nature·Simonas MasiulisA Radu Aricescu
Jul 3, 2019·Journal of Ethnopharmacology·Kamal M HamadGehad A Abdel Jaleel
Aug 28, 2020·Frontiers in Pharmacology·Denise Dias de OliveiraRenê O Beleboni
Jan 3, 2021·Biochemical and Biophysical Research Communications·Francisco Wagner Q Almeida-NetoHélcio Silva Dos Santos

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