Comedication with interacting drugs predisposes amiodarone users in cardiac and surgical intensive care units to acute liver injury: A retrospective analysis

Medicine
Yunn-Fang HoPing-Ing Lee

Abstract

Risk factors and underlying mechanisms for liver injury associated with amiodarone remain elusive. This study aimed to investigate the drug-related covariates for acute liver injury by amiodarone-an intriguing compound of high lipophilicity, with a long half-life and notable efficacy.The medical, pharmacy, and laboratory records of new amiodarone users admitted to the cardiac or surgical intensive care units of a medical center were examined retrospectively. A Cox regression model with time-varying dose-related variables of amiodarone was utilized to estimate the hazard ratio (HR) of amiodarone-associated liver injury while adjusting for concomitant therapy and relevant covariates.Of the 131 eligible patients among 6,572 amiodarone users (46,402 prescriptions), 6 were identified as amiodarone-associated liver injury cases. In comparison to controls (n = 125), this liver injury cohort (n = 6) had significantly higher numbers of amiodarone-interacting (2.7 ± 2.0 vs 0.9 ± 0.9 drugs, P = .02) and hepatotoxic (3.8 ± 0.8 vs 2.5 ± 1.7 drugs, P = .03) comedications. The number of comedications with amiodarone-interacting potential (HR 2.07, 95% confidence interval [CI] 1.02-4.22, P = .04) and amiodarone cumulative doses standardized by...Continue Reading

References

Dec 1, 1990·Critical Care Medicine·H Artucio, M Pereira
May 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M PirovinoU Honegger
Feb 19, 1987·The New England Journal of Medicine·J W Mason
Apr 1, 1993·Journal of Cardiovascular Electrophysiology·A VereckeiJ Feher
Oct 23, 1997·Cell Biochemistry and Function·S M RibeiroM L Kluppel
Dec 10, 2003·Medicine·Jean HenrionFrançis R Heller
Jan 14, 2004·Archives of Internal Medicine·Margaret C FangDaniel E Singer
Jan 13, 2005·Critical Care Medicine·Alexandra E Rätz BravoWolfgang Ummenhofer
Aug 9, 2005·Gastroenterology·Raúl J AndradeUNKNOWN Spanish Group for the Study of Drug-Induced Liver Disease
Sep 17, 2005·Scandinavian Journal of Gastroenterology·Einar BjörnssonRolf Olsson
Feb 17, 2006·The New England Journal of Medicine·Victor J Navarro, John R Senior
Sep 15, 2006·The Journal of Pharmacology and Experimental Therapeutics·Katri Maria WaldhauserStephan Krähenbühl
Mar 27, 2007·The Annals of Thoracic Surgery·Lars R ZebisVibeke E Hjortdal
Sep 4, 2007·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Nora GoldschlagerUNKNOWN Practice Guidelines Sub-committee, North American Society of Pacing and Electrophysiology (HRS)
Sep 20, 2007·JAMA : the Journal of the American Medical Association·Patricia Vassallo, Richard G Trohman
Jan 1, 2010·Cardiovascular & Hematological Disorders Drug Targets·Sujeeth R PunnamRanjan K Thakur
Jan 16, 2010·Expert Opinion on Drug Safety·Paul F SouneyDaniel J Cushing
Jul 22, 2010·The American Journal of Gastroenterology·Harshad DevarbhaviC K Adarsh
Dec 22, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Minjun ChenWeida Tong
Mar 13, 2014·Pharmacoepidemiology and Drug Safety·Amarsinh M DesaiChristina M L Kelton
Jun 18, 2014·The American Journal of Gastroenterology·Naga P ChalasaniUNKNOWN Practice Parameters Committee of the American College of Gastroenterology
Jan 31, 2015·The New England Journal of Medicine·Francis S Collins, Harold Varmus
Aug 14, 2015·Science Translational Medicine·Sam HawgoodKeith R Yamamoto

❮ Previous
Next ❯

Citations

Aug 29, 2019·Clinical and Translational Science·Yunn-Fang HoPing-Ing Lee

❮ Previous
Next ❯

Software Mentioned

R Foundation for Statistical Computing
R

Related Concepts

Related Feeds

Antiarrhythmic Agents: Mechanisms of Action

Understanding the mechanism of action of antiarrhythmic agents is essential in developing new medications as treatment of cardiac arrhythmias is currently limited by the reduced availability of safe and effective drugs. Discover the latest research on Antiarrhythmic Agents: Mechanism of Action here.

Related Papers

International Journal of Environmental Research and Public Health
Jelena UmbrasienėJon Venclovienė
International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
Luigi BrunettiDong-Churl Suh
© 2022 Meta ULC. All rights reserved