Coming up for air: HIF-1 and mitochondrial oxygen consumption

Cell Metabolism
M Celeste Simon

Abstract

Hypoxic cells induce glycolytic enzymes; this HIF-1-mediated metabolic adaptation increases glucose flux to pyruvate and produces glycolytic ATP. Two papers in this issue of Cell Metabolism (Kim et al., 2006; Papandreou et al., 2006) demonstrate that HIF-1 also influences mitochondrial function, suppressing both the TCA cycle and respiration by inducing pyruvate dehydrogenase kinase 1 (PDK1). PDK1 regulation in hypoxic cells promotes cell survival.

References

Mar 2, 2005·Neoplasia : an International Journal for Oncology Research·Michael I KoukourakisUNKNOWN Tumor and Angiogenesis Research Group

❮ Previous
Next ❯

Citations

Nov 17, 2007·Genes & Development·Devanjan Sikder, Thomas Kodadek
Dec 17, 2010·Molecular Cancer Therapeutics·Sarah E BohndiekKevin M Brindle
Jan 7, 2014·Acta Biochimica Et Biophysica Sinica·De HuangHuafeng Zhang
Jan 19, 2010·Annual Review of Pathology·Douglas C WallaceVincent Procaccio
Feb 11, 2016·Journal of Clinical Medicine·Shih-Han KaoWen-Hwa Lee
Jun 5, 2015·The Kaohsiung Journal of Medical Sciences·Shigeo SaitoKazunari K Yokoyama
Jul 5, 2013·Kidney International·Oscar C Y YangPatrick J Pollard
Jun 12, 2012·Gastroenterology·Nadja LehwaldKarl G Sylvester
Oct 23, 2010·Pharmacology & Therapeutics·Antonio Paolo BeltramiCarlo Alberto Beltrami
Feb 17, 2007·The FEBS Journal·Rafael Moreno-SánchezEmma Saavedra
Apr 27, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Balu K ChackoVictor M Darley-Usmar
Apr 9, 2013·International Journal of Cancer. Journal International Du Cancer·Ya-Ping Tsai, Kou-Juey Wu
Sep 3, 2009·Journal of Cellular Physiology·Pernilla Eliasson, Jan-Ingvar Jönsson
May 23, 2012·IEEE Journal of Biomedical and Health Informatics·M G KounelakisX Kotsiakis
Feb 27, 2016·Science·Isha H JainVamsi K Mootha
Nov 27, 2014·Annals of the New York Academy of Sciences·Denise ToscaniNicola Giuliani
Oct 23, 2010·Molecular Cell·Amar J MajmundarM Celeste Simon
Jan 18, 2014·Cancer Cell·Lindsay E WuDavid A Sinclair
May 18, 2016·Trends in Biochemical Sciences·Chenxia HeMarcelo G Bonini
Jul 21, 2017·American Journal of Human Biology : the Official Journal of the Human Biology Council·Allison J JanochaCynthia M Beall
Aug 15, 2018·Molecular Medicine Reports·Zhen ZhangGang Du
Apr 23, 2020·Frontiers in Genetics·Alessandra Jordano ConforteFabrício Alves Barbosa da Silva
Feb 19, 2015·Molecular Biology Reports·Rupert CourtnayTom C Karagiannis
Nov 26, 2020·Drug Design, Development and Therapy·Ruo-Lan LiChun-Jie Wu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.