PMID: 15229352Jul 2, 2004Paper

Commensal bacteria, redox stress, and colorectal cancer: mechanisms and models

Experimental Biology and Medicine
Mark M Huycke, H Rex Gaskins

Abstract

The potential role for commensal bacteria in colorectal carcinogenesis is explored in this review. Most colorectal cancers (CRCs) occur sporadically and arise from the gradual accumulation of mutations in genes regulating cell growth and DNA repair. Genetic mutations followed by clonal selection result in the transformation of normal cells into malignant derivatives. Numerous toxicological effects of colonic bacteria have been reported. However, those recognized as damaging epithelial cell DNA are most easily reconciled with the currently understood genetic basis for sporadic CRC. Thus, we focus on mechanisms by which particular commensal bacteria may convert dietary procarcinogens into DNA damaging agents (e.g., ethanol and heterocyclic amines) or directly generate carcinogens (e.g., fecapentaenes). Although these and other metabolic activities have yet to be linked directly to sporadic CRC, several lines of investigation are reviewed to highlight difficulties and progress in the area. Particular focus is given to commensal bacteria that alter the epithelial redox environment, such as production of oxygen radicals by Enterococcus faecalis or production of hydrogen sulfide by sulfate-reducing bacteria (SRB). Super-oxide-produci...Continue Reading

References

Mar 1, 1978·Veterinary Pathology·S W BartholdA M Jonas
Apr 15, 1975·International Journal of Cancer. Journal International Du Cancer·B Armstrong, R Doll
Mar 1, 1991·Mutation Research·A C PoveyC C Harris
Jan 1, 1990·Reviews of Infectious Diseases·S L Gorbach, B R Goldin
Jan 1, 1990·Free Radical Biology & Medicine·C F Babbs
Dec 1, 1990·The Journal of Applied Bacteriology·G R Gibson
Oct 1, 1987·Carcinogenesis·M J HinzmanA M Shamsuddin
Jan 1, 1986·Microbiology and Immunology·Y BennoT Mitsuoka
Jul 1, 1971·Cancer·D P Burkitt
Jun 1, 1984·Journal of Clinical Pathology·W E RoedigerP R Pannall
Nov 1, 1984·The Journal of Clinical Investigation·F R DeRubertisR Saito
Sep 1, 1995·Applied and Environmental Microbiology·W E Moore, L H Moore
Nov 1, 1993·Mutation Research·A M Roberton
Feb 15, 1995·Journal of the National Cancer Institute·E GiovannucciW C Willett
Jan 27, 1995·International Journal of Cancer. Journal International Du Cancer·A HagueC Paraskeva
Mar 1, 1995·Annals of Internal Medicine·E GiovannucciW C Willett
Oct 1, 1994·Environmental Health Perspectives·E A SweeneyS J Forsythe
Dec 1, 1994·Carcinogenesis·D K ScatesS Venitt
Jul 1, 1993·Carcinogenesis·M ZarkovicT Ishikawa
Aug 4, 1993·Journal of the National Cancer Institute·T M de KokJ C Kleinjans
Jan 1, 1993·Nutrition and Cancer·C J RumneyI K O'Neill
Apr 1, 1996·Clinical and Experimental Immunology·P PavliF Doe
Mar 1, 1996·The Journal of Infectious Diseases·M M HuyckeM F Wack
Jul 1, 1996·Applied and Environmental Microbiology·K H Wilson, R B Blitchington

❮ Previous
Next ❯

Citations

Nov 27, 2004·Experimental Biology and Medicine·Danny R MooreMark M Huycke
Nov 28, 2006·Nature Methods·Brian V Jones, Julian R Marchesi
Jun 26, 2007·Diseases of the Colon and Rectum·Maren K FuentesEmina H Huang
Aug 2, 2007·Biological & Pharmaceutical Bulletin·Hong XueJin Xia Zhu
Feb 2, 2010·Environmental and Molecular Mutagenesis·Matias S Attene-RamosH Rex Gaskins
Sep 30, 2010·Critical Reviews in Microbiology·Marco CandelaCarla Fiorentini
Feb 25, 2011·Journal of Clinical Gastroenterology·Cristiano PagniniGianfranco Delle Fave
Aug 8, 2012·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Kishore Vipperla, Stephen J O'Keefe
Aug 28, 2012·Journal of Biosciences·Deepak P PatilYogesh S Shouche
Nov 23, 2012·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Dae Seong Myung, Young Eun Joo
Nov 28, 2012·The ISME Journal·Sahar El AidyMichiel Kleerebezem
Dec 5, 2013·Carcinogenesis·Scott J Bultman
Feb 18, 2017·Genome Announcements·Udo WegmannArjan Narbad
May 10, 2017·CA: a Cancer Journal for Clinicians·Aadra P BhattScott J Bultman
Apr 21, 2017·Carcinogenesis·Giovanni BrandiGuido Biasco
Mar 11, 2018·Clinical Science·Wei Ling LauNosratola D Vaziri
May 1, 2018·Oncotarget·Domenica ReaClaudio Arra
Dec 18, 2018·Proteomics·Putri-Intan-Hafizah Megat Mohd AzlanRahman Jamal
Jul 17, 2008·Current Gastroenterology Reports·James M KinrossJeremy K Nicholson
Dec 15, 2005·Nutrition and Cancer·Yuqing Yang, Daniel D Gallaher
Aug 8, 2008·Journal of Clinical Gastroenterology·Cristiano PagniniGianfranco Delle Fave
Dec 31, 2008·World Journal of Gastroenterology : WJG·Volker Mai, Peter V Draganov
Feb 11, 2010·Future Microbiology·Jun HanChristoph H Borchers
Apr 7, 2011·Gut Microbes·Brian V Jones
Feb 16, 2015·Archivum Immunologiae Et Therapiae Experimentalis·Magdalena MuszerMikael Skurnik
Jun 8, 2017·Experimental and Therapeutic Medicine·Xiaoxue WangLi Deng
Dec 6, 2017·Journal of Clinical Gastroenterology·Parth J ParekhDavid A Johnson
Feb 23, 2018·The ISME Journal·Karthik AnantharamanJillian F Banfield
Sep 13, 2018·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Agampodi Promoda PereraHeinrich Körner
Dec 6, 2018·Frontiers in Microbiology·Jing CongXiaochun Zhang
Sep 18, 2020·Microbial Biotechnology·Keke ZhangQingyun Yan
May 9, 2008·Current Infectious Disease Reports·Shervin Rabizadeh, Cynthia Sears
Mar 29, 2006·Journal of Translational Medicine·D L Mager
Mar 3, 2010·Annual Review of Immunology·David A Hill, David Artis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Molecular Cancer Research : MCR
Matias S Attene-RamosMichael J Plewa
The Journal of Nutrition
Radoslav Goldman, P G Shields
Molecular Cancer Research : MCR
Matias S Attene-RamosH Rex Gaskins
© 2022 Meta ULC. All rights reserved