Commensal microbes and p53 in cancer progression.

Biology Direct
Ivana CelardoIvano Amelio

Abstract

Aetiogenesis of cancer has not been fully determined. Recent advances have clearly defined a role for microenvironmental factors in cancer progression and initiation; in this context, microbiome has recently emerged with a number of reported correlative and causative links implicating alterations of commensal microbes in tumorigenesis. Bacteria appear to have the potential to directly alter physiological pathways of host cells and in specific circumstances, such as the mutation of the tumour suppressive factor p53, they can also directly switch the function of a gene from oncosuppressive to oncogenic. In this minireview, we report a number of examples on how commensal microbes alter the host cell biology, affecting the oncogenic process. We then discuss more in detail how interaction with the gut microbiome can affect the function of p53 mutant in the intestinal tumorigenesis.

References

Nov 19, 1993·Cell·W S el-DeiryB Vogelstein
Jan 19, 2000·Cell Death and Differentiation·M LevreroJ Y Wang
Feb 13, 2004·Development·Nathalie BillonMartin Raff
Mar 31, 2004·Transplantation Proceedings·P SileriA L Gaspari
Aug 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Mario RossiGerry Melino
Nov 10, 2006·Journal of Cell Science·Eleonora CandiGerry Melino
Apr 24, 2008·Nature Reviews. Molecular Cell Biology·Todd RileyArnold Levine
Sep 23, 2008·Genes & Development·Richard TomasiniTak W Mak
Dec 2, 2008·Nature Reviews. Drug Discovery·Alexei VazquezGareth L Bond
Jan 14, 2009·Proceedings of the National Academy of Sciences of the United States of America·Richard TomasiniTak W Mak
Apr 7, 2009·Cell·Maddalena AdornoStefano Piccolo
Jan 13, 2010·Cell·Patricia A J MullerKaren H Vousden
Sep 9, 2010·Infection and Immunity·Christopher W KaplanWenyuan Shi
Oct 5, 2010·Biochemical and Biophysical Research Communications·Anna Maria LenaEleonora Candi
May 23, 2013·Nature Communications·Olivier PapapietroSamantha Gruenheid
May 25, 2013·Cell Death & Disease·I CelardoI Amelio
Mar 25, 2014·Oncotarget·Ivana CelardoGerry Melino
Aug 30, 2014·Cell Death and Differentiation·E CandiG Melino
Dec 17, 2014·Oncotarget·Ivano AmelioAlessandro Rufini
Dec 24, 2014·Proceedings of the National Academy of Sciences of the United States of America·Ivano AmelioGerry Melino
Feb 18, 2015·Nature Reviews. Gastroenterology & Hepatology·Georgina L Hold, Wendy S Garrett
Apr 4, 2015·Science·Wendy S Garrett
Jun 3, 2015·Trends in Biochemical Sciences·Ivano Amelio, Gerry Melino
Feb 27, 2016·Cell Death and Differentiation·I AmelioA V Antonov
Apr 7, 2016·Cold Spring Harbor Perspectives in Medicine·Ashley B Williams, Björn Schumacher
Nov 1, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kensuke YamamuraHideo Baba
Sep 25, 2017·Cell Death and Differentiation·Cédric CastrogiovanniPatrick Dumont
Oct 28, 2017·Cell Death and Differentiation·Alice NemajerovaUte M Moll
Nov 4, 2017·Cell Death and Differentiation·Alyssa M Kaiser, Laura D Attardi
Nov 11, 2017·Cell Death and Differentiation·Kelly D SullivanJoaquin M Espinosa
Nov 11, 2017·Cell Death and Differentiation·Kurt Engeland
Dec 2, 2017·Cell Death and Differentiation·Danyi Wu, Carol Prives
Dec 15, 2017·Cell Death and Differentiation·Alejandro ParralesTomoo Iwakuma
Feb 7, 2018·Molecular & Cellular Oncology·Leore T Geller, Ravid Straussman
Mar 14, 2018·Cell Death Discovery·Victoire Gouirand, Sophie Vasseur
Apr 5, 2018·Biology Direct·Margherita FrancescattoCesare Furlanello
Apr 5, 2018·Cell Cycle·Omid TavanaWei Gu

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Citations

Jul 11, 2021·Molecular Oncology·Carlo GaniniGerry Melino
Jun 14, 2021·Journal of Molecular Biology·Alessio ButeraIvano Amelio
Aug 6, 2021·Biology Direct·Eleonora MammarellaIvano Amelio
Aug 8, 2021·Biology Direct·Emanuele PanattaIvano Amelio

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