Commensal Microbes Induce Serum IgA Responses that Protect against Polymicrobial Sepsis

Cell Host & Microbe
Joel R WilmoreDavid Allman

Abstract

Serum immunoglobulin A (IgA) antibodies are readily detected in mice and people, but the mechanisms underlying the induction of serum IgA and its role in host protection remain uncertain. We report that select commensal bacteria induce several facets of systemic IgA-mediated immunity. Exposing conventional mice to a unique but natural microflora that included several members of the Proteobacteria phylum led to T cell-dependent increases in serum IgA levels and the induction of large numbers of IgA-secreting plasma cells in the bone marrow. The resulting serum IgA bound to a restricted collection of bacterial taxa, and antigen-specific serum IgA antibodies were readily induced after intestinal colonization with the commensal bacterium Helicobacter muridarum. Finally, movement to a Proteobacteria-rich microbiota led to serum IgA-mediated resistance to polymicrobial sepsis. We conclude that commensal microbes overtly influence the serum IgA repertoire, resulting in constitutive protection against bacterial sepsis.

Citations

Jul 19, 2018·Medical Sciences : Open Access Journal·Majda DzidicMaria Carmen Collado
Sep 28, 2018·Journal of Leukocyte Biology·Mathew A HugginsSara E Hamilton
Mar 5, 2019·Beneficial Microbes·V B M PetersM Meijerink
Mar 16, 2019·Immunological Reviews·David AllmanBrian T Gaudette
Mar 6, 2018·Nature Reviews. Immunology·Yvonne Bordon
Mar 29, 2018·Nature Reviews. Drug Discovery·Sarah Crunkhorn
May 28, 2019·Immunology and Cell Biology·Kathy D McCoyMarkus B Geuking
May 19, 2018·Molecular Systems Biology·Steven Timmermans, Claude Libert
Jul 17, 2019·JCI Insight·Yuk Man LeiMaria-Luisa Alegre
Jul 16, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Katherine T FayCraig M Coopersmith
Oct 3, 2019·Cellular and Molecular Life Sciences : CMLS·Max Van BelkumJosef Neu
Jan 1, 2020·The Journal of Experimental Medicine·Delphine SterlinGuy Gorochov
Mar 17, 2020·EMBO Molecular Medicine·Jean-Marc CavaillonTomasz Skirecki
Apr 17, 2020·JCI Insight·Juan HuangLi Wen
Jul 17, 2020·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Jesse CrayleRichard Bedlack
Jul 1, 2018·The Journal of Experimental Medicine·Simon Le GallouClaude-Agnès Reynaud
Sep 27, 2018·Scientific Reports·Stephanie S GervasiBruce A Kimball
Mar 13, 2019·Nature Reviews. Immunology·Ashwin N SkellyKenya Honda
Apr 16, 2019·Frontiers in Immunology·Annelot Breedveld, Marjolein van Egmond
Dec 5, 2019·Journal of Nutritional Science·Robin MesnageFrançoise Wilhelmi de Toledo
Feb 6, 2020·Nature Reviews. Immunology·Kang ChenAndrea Cerutti
Jun 4, 2020·Critical Care : the Official Journal of the Critical Care Forum·Max W AdelmanGreg S Martin
Sep 27, 2018·Frontiers in Immunology·Bastiaan W HaakW Joost Wiersinga
Aug 16, 2019·Mucosal Immunology·Delphine SterlinGuy Gorochov
Dec 11, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Natalia V GiltiayEdward A Clark
Sep 25, 2018·Scandinavian Journal of Immunology·David Usharauli, Tirumalai Kamala
Feb 10, 2019·Nature Communications·Sadeesh K RamakrishnanYatrik M Shah
Oct 23, 2019·Signal Transduction and Targeted Therapy·Ziying ZhangYongguang Tao
Oct 8, 2020·Current Protocols in Immunology·Frances V SjaastadThomas S Griffith
Aug 30, 2020·The Journal of Clinical Endocrinology and Metabolism·Juan HuangLi Wen
Oct 28, 2020·Immunological Reviews·Angela WangJennifer L Gommerman
Oct 25, 2020·Journal of Animal Science·Jinsu HongTofuko Awori Woyengo

❮ Previous
Next ❯

Related Concepts

Related Feeds

B cell Differentiation

Depending on the signal received through the B cell receptor and other receptors, B cells differentiate into follicular or marginal zone B cells. Here is the latest research pertaining to this differentiation process.

Antibody Repertoire Diversity

Antibody repertoire diversity and its role during natural infection is a prerequisite for molecular and structural elucidation of functionally protective immunity. Discover the latest insights into antibody diversity here.