Commensal microbiota and host metabolic divergence are associated with the adaptation of Diploderma vela to spatially heterogeneous environments.

Integrative Zoology
Wei ZhuJianping Jiang


Heterogeneous environment adaptation is critical to understand the species evolution and response to climate change. However, how narrow-range species adapt to micro-geographic heterogeneity has been overlooked, and there is a lack of insights from metabolism and commensal microbiota. Here, we studied the environmental adaptation for 3 geographic populations (>40 km apart) of Diploderma vela, a lizard endemic to dry-hot valleys of the Hengduan Mountain Region. The climatic boundary caused a cooler, droughtier, and barren environment for northernmost population (RM) than the middle (QZK) and southernmost populations (FS). Correspondingly, significant divergences in liver and muscle metabolism and commensal microbiota were detected between RM and QZK or FS individuals, but not between QZK and FS individuals. Phospholipid composition, coenzyme level (i.e. pyridoxal and NAD+ ), and cholesterol metabolism (e.g. androgen and estriol synthesis) constituted the major metabolic difference between RM and QZK/FS groups. FS and QZK individuals kept abundant Proteobacteria and antifungal strains, while RM individuals maintained more Firmicutes and Bacteroidota. Strong associations existed between varied host metabolite and gut microbes. How...Continue Reading


Jan 1, 1985·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·J R Hazel, R Carpenter
Feb 1, 1985·Experimental Neurology·S Suzuki, T Yamamuro
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·P W HochachkaS C Land
Jul 17, 1998·Nature·P B Rainey, M Travisano
Mar 8, 2000·Nature·N MyersJ Kent
Apr 5, 2001·Nature·J M KieseckerL K Belden
Sep 2, 2003·EMBO Reports·Riccardo Percudani, Alessio Peracchi
May 27, 2004·Journal of Muscle Research and Cell Motility·Kathleen M McCormickGayle A Brazeau
Jun 11, 2004·Annual Review of Biochemistry·Isao IshiiJerold Chun
Jun 12, 2004·Biological Reviews of the Cambridge Philosophical Society·Helga Guderley
Oct 9, 2004·The Journal of Clinical Endocrinology and Metabolism·Indrani Sinha-HikimShalender Bhasin
Jun 11, 2005·Epilepsia·Rafal M KaminskiMichael A Rogawski
Oct 21, 2006·The Journal of Physiological Sciences : JPS·Takao SugiuraScott K Powers
Dec 7, 2006·Proceedings. Biological Sciences·Jaime BoschMatthew C Fisher
Mar 23, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·David A AnderssonStuart Bevan
Feb 6, 2008·General and Comparative Endocrinology·Sarah E DurantWilliam A Hopkins
Sep 3, 2008·General and Comparative Endocrinology·Xiangdong Li, Nafis Rahman
Oct 25, 2008·Nature·Jeremy K Nicholson, John C Lindon
Nov 22, 2008·Science·John EidStephen Turner
Aug 15, 2009·Trends in Ecology & Evolution·Frances BonierJohn C Wingfield
Oct 23, 2009·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Amanda Southwood, Larisa Avens
Apr 29, 2010·The Journal of Clinical Investigation·Amol M PatwardhanKenneth M Hargreaves
May 15, 2010·Science·Barry SinervoJack W Sites
Jul 21, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jing CheYa-Ping Zhang
Nov 19, 2010·Nature Reviews. Genetics·Joy Bergelson, Fabrice Roux
Jan 5, 2011·Protein & Cell·Baoli ZhuLanjuan Li
Jun 28, 2011·Genome Biology·Nicola SegataCurtis Huttenhower
Dec 14, 2011·Biochemistry. Biokhimii︠a︡·I K Kolomiytseva
Feb 15, 2012·Proceedings of the National Academy of Sciences of the United States of America·Vladimír KoštálTomáš Štětina
Apr 14, 2012·Nature·Matthew C FisherSarah J Gurr
Nov 30, 2012·Nucleic Acids Research·Christian QuastFrank Oliver Glöckner
Aug 27, 2013·Nature Biotechnology·Morgan G I LangilleCurtis Huttenhower
Oct 19, 2013·Nature Reviews. Genetics·Outi SavolainenJuha Merilä
Feb 8, 2014·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Alice M ReynoldsJon P Costanzo

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.