Commensal microbiota divergently affect myeloid subsets in the mammalian central nervous system during homeostasis and disease.

The EMBO Journal
Roman SankowskiDaniel Erny


The immune cells of the central nervous system (CNS) comprise parenchymal microglia and at the CNS border regions meningeal, perivascular, and choroid plexus macrophages (collectively called CNS-associated macrophages, CAMs). While previous work has shown that microglial properties depend on environmental signals from the commensal microbiota, the effects of microbiota on CAMs are unknown. By combining several microbiota manipulation approaches, genetic mouse models, and single-cell RNA-sequencing, we have characterized CNS myeloid cell composition and function. Under steady-state conditions, the transcriptional profiles and numbers of choroid plexus macrophages were found to be tightly regulated by complex microbiota. In contrast, perivascular and meningeal macrophages were affected to a lesser extent. An acute perturbation through viral infection evoked an attenuated immune response of all CAMs in germ-free mice. We further assessed CAMs in a more chronic pathological state in 5xFAD mice, a model for Alzheimer's disease, and found enhanced amyloid beta uptake exclusively by perivascular macrophages in germ-free 5xFAD mice. Our results aid the understanding of distinct microbiota-CNS macrophage interactions during homeostasis ...Continue Reading


Jan 24, 2009·Proceedings of the National Academy of Sciences of the United States of America·Cheryl A Hawkes, Joanne McLaurin
Feb 28, 2009·International Immunology·Taro Kawai, Shizuo Akira
Aug 5, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alexander MildnerMarco Prinz
Mar 30, 2012·Omics : a Journal of Integrative Biology·Guangchuang YuQing-Yu He
Mar 26, 2013·Nature Neuroscience·Masaki UenoToshihide Yamashita
Dec 10, 2013·Nature Neuroscience·Oleg ButovskyHoward L Weiner
Mar 19, 2014·Cell Host & Microbe·Arya KhosraviSarkis K Mazmanian
May 20, 2014·Nature Methods·Peter V KharchenkoDavid T Scadden
Jun 20, 2014·Brain Pathology·Cheryl A HawkesRoxana O Carare
Feb 18, 2015·Nature Immunology·Michael T HenekaEicke Latz
Jun 2, 2015·Nature Neuroscience·Daniel ErnyMarco Prinz
Sep 17, 2015·Nature·Dachuan ZhangPaul S Frenette
Jan 17, 2016·Neurobiology of Disease·Patrizia GiannoniNicola Marchi
May 3, 2016·Nature Immunology·Tobias GoldmannMarco Prinz
Jun 28, 2016·Cell Stem Cell·Dominic GrünAlexander van Oudenaarden
Sep 17, 2016·Genome Announcements·Yasuhiro UchimuraAndrew J Macpherson
Nov 15, 2016·The Journal of Clinical Investigation·Giuseppe FaracoCostantino Iadecola
Mar 23, 2017·Nature Immunology·Marco PrinzNora Hagemeyer
Jun 22, 2017·Immunity·Jasmin HerzJonathan Kipnis
Oct 21, 2017·Genome Announcements·Debora GarzettiBärbel Stecher
Feb 25, 2018·Cellular Immunology·Guillaume Hoeffel, Florent Ginhoux
Apr 10, 2018·Nature Methods·Josip S HermanDominic Grün
Jun 11, 2019·Cell·Tim StuartRahul Satija
Jul 31, 2019·Nature Reviews. Neuroscience·Katrin KierdorfMarco Prinz
Jan 8, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Simone BrioschiMarco Colonna
Mar 18, 2020·Glia·Daniel Erny, Marco Prinz
Apr 29, 2020·Nature Biotechnology·Jiarui DingJoshua Z Levin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: Microglia

Microglia are a type of glial cell found throughout the brain and spinal cord. Microglia have been found to be associated with Alzheimer's disease development and progression. Here are the latest discoveries pertaining to Alzheimer's disease and microglia.

Alzheimer's Disease: Transcription

Impaired transcription is associated with the pathogenesis and progression of conditions such as Alzheimer's disease (AD). Here are the latest discoveries pertaining to transcription and AD.

Alzheimer's Disease: Animal Models

Alzheimer's disease is a neurodegenerative disease which can be studied using various experimental systems. This feed focuses on animal models used for Alzheimer's disease research.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

© 2021 Meta ULC. All rights reserved