Comment on Saber et al. (2019), "Commentary: the chronic inhalation study in rats for assessing lung cancer risk may be better than its reputation"

Particle and Fibre Toxicology
Kevin E DriscollGünter Oberdörster

Abstract

In their Commentary Saber et al. (Part Fibre Toxicol 16: 44, 2019) argue that chronic inhalation studies in rats can be used for assessing the lung cancer risk of insoluble nanomaterials. The authors make several significant errors in their interpretation and representation of the underlying science. In this Letter to the Editor we discuss these inaccuracies to correct the scientific record. When the science is recounted accurately it does not support Saber et al's statements and conclusions.

References

Feb 1, 1995·Regulatory Toxicology and Pharmacology : RTP·G Oberdörster
Sep 24, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Alison ElderGünter Oberdörster
Apr 1, 2009·Journal of Occupational and Environmental Medicine·Robert J McCunneyStephen Payne
Nov 5, 2013·Occupational and Environmental Medicine·Judith M GraberMichael D Attfield
Mar 15, 2018·Journal of Occupational and Environmental Medicine·Hien Q LeElizabeth D Ellis
Oct 27, 2018·Regulatory Toxicology and Pharmacology : RTP·Ruth J BevanDavid B Warheit
Sep 13, 2019·Journal of Occupational and Environmental Medicine·Mei YongRobert J McCunney
Mar 10, 2020·Inhalation Toxicology·Kevin E Driscoll, Paul J A Borm

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