Comment on the paper "Comparison of the measured phase diagrams in the force-temperature plane for the unzipping of two different natural DNA sequences" by C.H. Lee, C. Danilowicz, V.W. Coljee, and M. Prentiss

The European Physical Journal. E, Soft Matter
S Cocco

Abstract

The paper by Lee et al. describes the experiments on the unzipping of lambda DNA sequences as a function of force and temperature. This comment aims to stress that the unzipping takes place out of equilibrium due to high sequence-dependent free-energy barriers. The force at which a heterogeneous sequence is unzipped therefore depends on the experimental waiting time.

References

Apr 1, 1997·Biophysical Journal·E Evans, K Ritchie
Sep 6, 2000·Physical Review Letters·D K Lubensky, D R Nelson
Apr 28, 2001·Science·J LiphardtC Bustamante
Aug 18, 2001·Biophysical Journal·U GerlandT Hwa
Feb 28, 2002·Biophysical Journal·U BockelmannF Heslot
Mar 11, 2004·The European Physical Journal. E, Soft Matter·S CoccoR Monasson
Mar 12, 2004·The European Physical Journal. E, Soft Matter·S CoccoJ Yan

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Citations

Aug 27, 2009·The Journal of Physical Chemistry. B·Srividya MohanLoren Dean Williams

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