Commentary: lessons from molecular genetic studies on reporting false-positive results.

Reproduction, Fertility, and Development
G W Montgomery

Abstract

Poor replication of published research results is the subject of debate. A common problem is the failure to adequately account for multiple testing issues. In this regard, the evolution of mapping studies to identify genetic risk factors for common diseases has been instructive. Large genome-wide association studies (GWAS) reliably detect the genetic factors with small effects that contribute to risk for many common diseases. GWAS superseded candidate gene studies from the previous decade and looking back, almost no genetic risk factors reported from earlier candidate gene studies replicate in the GWAS results. Candidate gene studies often used small samples and failed to appreciate and adequately account for the multiple testing issues. The failure to replicate results from most candidate gene studies highlights the importance of study power and appropriate statistical analysis to prevent publication of false-positive results.

References

Oct 29, 2005·Nature·UNKNOWN International HapMap Consortium
Jun 7, 2008·Human Reproduction Update·Grant W MontgomeryKrina T Zondervan
Aug 28, 2012·Current Obstetrics and Gynecology Reports·Nilufer RahmiogluKrina T Zondervan
Sep 27, 2012·Psychological Science·Christopher F ChabrisDavid Laibson
Jan 7, 2016·European Journal of Human Genetics : EJHG·João FadistaLeif Groop
Jul 8, 2017·American Journal of Human Genetics·Peter M VisscherJian Yang
Oct 13, 2017·Nature·UNKNOWN GTEx ConsortiumStephen B Montgomery
Apr 15, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Laramie E DuncanJacob Ballon
Feb 28, 2020·Human Reproduction·Sally MortlockGrant W Montgomery

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