Commentary on 2 Cases of Takotsubo Cardiomyopathy Involving Psychotropic Medication

Journal of Psychiatric Practice
Marcia L Verduin


Takotsubo cardiomyopathy, also known as Takotsubo syndrome (TTS), is a cardiac syndrome first described in Japan in 1990 that typically follows an acute physical or psychiatric stressor, hence its association with the terms "broken heart syndrome" and stress cardiomyopathy. Although it is relatively rare, occurring in only 0.02% of the general population and roughly 2% of patients with acute coronary syndrome, neurological or psychiatric disorders are present in over 50% of affected individuals. One of the major hypotheses regarding the pathophysiology of TTS involves a catecholamine surge, from stress directly, or in some cases from psychiatric medication used to relieve distress. Given the association of TTS with acute stress and psychiatric illness, psychiatrists may be involved in the care of patients with TTS either at the initial presentation of the condition or following recovery. The case reports presented in this issue exemplify these 2 scenarios: one case involves the development of TTS during treatment with atomoxetine, and the other case involves treatment of depression in a patient after recovery from TTS, as well as a TTS recurrence during treatment with fluoxetine.


Jun 24, 2008·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Sophie De RoockPhilippe Hantson
May 19, 2009·Paediatric Drugs·Karly P Garnock-Jones, Gillian M Keating
May 28, 2009·Nature Reviews. Cardiology·Abhiram PrasadPanithaya Chareonthaitawee
Nov 16, 2013·European Journal of Pediatrics·Hiroshi YamaguchiSatoru Kumaki
Apr 29, 2014·International Journal of Cardiology·Andre DiasHenry C Quevedo
Jan 19, 2016·Global Cardiology Science & Practice·Kerolos Wagdy, Mohamed ElMaghawry
Apr 29, 2016·Journal of Psychiatric Practice·Ahmed NaguyAli Al-Tajali
Apr 29, 2016·Journal of Psychiatric Practice·Suki K ConradGlenn Catalano

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Sep 13, 2014·International Journal of Cardiology·Josef Finsterer, Karim Wahbi

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