Commentary to Gorelenkova Miller and Mieyal (2015): sulfhydryl-mediated redox signaling in inflammation: role in neurodegenerative diseases

Archives of Toxicology
Masashi KatoMasafumi Yoshinaga

Abstract

Gorelenkova Miller and Mieyal (Arch Toxicol 89(9): 1439-1467, 2015) recently published a review paper suggesting that reversible cysteine plays a key role in redox-linked signal transduction via alteration of protein function, resulting in an association with many diseases including neurodegenerative disorders. Following their suggestions, we considered the correlation between sulfhydryl-mediated redox signaling and neurodegenerative diseases by focusing on RET proteins, a protein tyrosine kinases (PTKs) potentially sited upstream of the signal transduction cascade. c-RET is the receptor for glial cell line-derived neurotrophic factor family ligands. c-RET has been reported to be involved in not only Hirschsprung disease via development of the enteric nervous system but also neurodegenerative diseases including Parkinson's disease and amyotrophic lateral sclerosis. We also showed that c-RET might be associated with hearing loss via neurodegeneration of spiral ganglion neurons in the inner ear after birth in mice and humans. Moreover, we have reported that three kinds of oxidative stress, ultraviolet light-induced stress, osmotic stress and arsenic-induced stress, modulate kinase activity of RET-PTC1 without an extracellular dom...Continue Reading

References

Oct 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·K HossainI Nakashima
Jul 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Nobutaka OhgamiMasashi Kato
Jan 5, 2011·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Masashi KatoNobutaka Ohgami
Feb 2, 2011·Laboratory Investigation; a Journal of Technical Methods and Pathology·Hoon RyuJunghee Lee
May 27, 2011·Neurobiology of Aging·Nobutaka OhgamiMasashi Kato
Apr 25, 2012·Archives of Toxicology·Ichiro YajimaMasashi Kato
Apr 2, 2015·Archives of Toxicology·Olga Gorelenkova Miller, John J Mieyal

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Citations

May 29, 2020·Environmental Health and Preventive Medicine·Masashi KatoIchiro Yajima

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