Comments on recent reports on infrared spectral detection of disease markers in blood components

Journal of Biophotonics
Max Diem

Abstract

The search for disease markers in whole blood, or easily accessible blood components by spectral methods is a highly important aspect in the field of biophotonic research for disease diagnostics and screening, since it promises a minimally invasive approach to assess an individual's state of health. Fourier transform infrared spectroscopy, in particular, promises to be a fast, inexpensive method to search for markers of disease, since it detects variation in the proteome, lipidome and metabolome of biofluids, or activation of immune cells. However, the analysis of any materials by spectral methods is confounded by external factors such as those related to sample deposition and data acquisition, and by inherent variations in blood plasma concentration of small molecules (lactate, carbonate, phosphate, glucose) that varies between individual subjects and even for a given individual, as a function of time. Furthermore, observed differences in spectral patterns between patient samples and the control group may be due to the body's immune response (in particular, to the albumin to globulin ratio) and therefore, may not be specific to disease. These factors need to be accounted for in any effort to reliably detect much smaller variat...Continue Reading

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Citations

Feb 27, 2019·Analytical and Bioanalytical Chemistry·Stéphane DerruauOlivier Piot
Nov 18, 2018·The Analyst·Katharina IsenseeWolfgang Petrich
Nov 25, 2020·Journal of Biophotonics·Stéphane DerruauSandrine Lorimier
Sep 29, 2018·Applied Spectroscopy·Susanne PahlowRohit Bhargava
Jan 16, 2021·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Thomas G MayerhöferJürgen Popp
Apr 22, 2021·Angewandte Chemie·Liudmila VoroninaMihaela Žigman
Dec 4, 2021·BMC Cancer·Kosmas V KepesidisJean-Marc Nabholtz

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