Commercial Cannabinoid Oil-Induced Stevens-Johnson Syndrome

Case Reports in Ophthalmological Medicine
Han Y YinSamuel Alpert

Abstract

To report an unusual presentation of commercial cannabidiol (CBD) oil-induced Stevens-Johnson Syndrome/toxic epidermal necrolysis (SJS-TEN). A 56-year-old woman presented with acute onset of a diffuse, blistering, maculopapular rash with over 30% total body surface area (BSA) involvement two days after taking CBD oil sublingually for chronic pain. Biopsy confirmed SJS-TEN. Ophthalmology was consulted and mild eye involvement was found. She was started on topical cyclosporine, prednisone, moxifloxacin, and erythromycin ointment to prevent progression, which was successful. She was otherwise treated with supportive therapy in the intensive care burn unit and ultimately passed away from septic shock. In this case, we described an unusual drug-induced SJS from a commercial, non-FDA-regulated cannabis product. The use of a commercial CBD product should be cautioned due to potential for series of drug reactions to the cannabis product and the risk for reaction to other unregulated other pharmacological components.

References

Apr 2, 2004·Nature·Wen-Hung ChungYuan-Tsong Chen
Oct 5, 2006·Current Pharmaceutical Design·Maria Teresa VenturaAntonino Romano
Mar 17, 2009·American Journal of Ophthalmology·Yayoi ArakiShigeru Kinoshita
Oct 22, 2011·Expert Review of Clinical Immunology·Maja Mockenhaupt
Jul 23, 2013·Journal of the American Academy of Dermatology·Robert A SchwartzBrian W Lee
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Nov 14, 2018·Dermatitis : Contact, Atopic, Occupational, Drug·Cory PettitMark Bechtel

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