Commercial Ethyl Glucuronide (EtG) and Ethyl Sulfate (EtS) Testing is Not Vulnerable to Incidental Alcohol Exposure in Pregnant Women

Substance Use & Misuse
Steven J OndersmaRobert J Sokol

Abstract

Ethyl Glucoronide (EtG) and Ethyl Sulfate (EtS) have shown promise as biomarkers for alcohol and may be sensitive enough for use with pregnant women in whom even low-level alcohol use is important. However, there have been reports of over-sensitivity of EtG and EtS to incidental exposure to sources such as alcohol-based hand sanitizer. Further, few studies have evaluated these biomarkers among pregnant women, in whom the dynamics of these metabolites may differ. This study evaluated whether commercial EtG-EtS testing was vulnerable to high levels of environmental exposure to alcohol in pregnant women. Two separate samples of five nurses-one pregnant and the other postpartum, all of whom reported high levels of alcohol-based hand sanitizer use-provided urine samples before and 4-8 hours after rinsing with alcohol-based mouthwash and using hand sanitizer. The five pregnant nurses provided urine samples before, during, and after an 8-hour nursing shift, during which they repeatedly cleansed with alcohol-based hand sanitizer (mean 33.8 uses). The five postpartum nurses used hand sanitizer repeatedly between baseline and follow-up urine samples. No urine samples were positive for EtG-EtS at baseline or follow-up, despite use of mout...Continue Reading

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Citations

Feb 17, 2017·Maternal Health, Neonatology and Perinatology·Jillian LasloJoseph Horzempa
Sep 26, 2020·Neuroscience and Biobehavioral Reviews·Stefania CiafrèMarco Fiore
Jan 14, 2021·Basic & Clinical Pharmacology & Toxicology·Nete Lundager Klokker RausgaardPer Damkier

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