Commercially Relevant Orthogonal Multi-Component Supramolecular Hydrogels for Programmed Cell Growth

Chemistry : a European Journal
Vânia M P VieiraDavid K Smith

Abstract

This study reports the ability of synthetically simple, commercially viable sugar-derived 1,3:2,4-dibenzylidenesorbitol-4',4"-diacylhydrazide (DBS-CONHNH2 ) to support cell growth. Simple mixing and orthogonal self-sorting can formulate heparin, agarose, and heparin-binding micelles into these gels-easily incorporating additional function. Interestingly, the components used in the gel formulation, direct the ability of cells to grow, meaning the chemical programming of these multi-component gels is directly translated to the biological systems in contact with them. This simple approach has potential for future development in regenerative medicine.

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Citations

Jun 27, 2019·Chemistry : a European Journal·Carmen C Piras, David K Smith
Aug 3, 2019·Macromolecular Bioscience·Aurica P ChiriacVlad Mihai Chiriac
Nov 8, 2019·Angewandte Chemie·Carmen C PirasDavid K Smith
Aug 19, 2020·Chemical Communications : Chem Comm·Anna K Patterson, David K Smith
Jan 16, 2019·Nanomaterials·Alexey V Medved'koSergey Z Vatsadze
Dec 8, 2020·Beilstein Journal of Organic Chemistry·Amit Ghosh, Michael Schmittel
Jun 25, 2021·Chemical Science·Lisa SchlichterDavid K Smith
Oct 22, 2019·Chemistry of Materials : a Publication of the American Chemical Society·Babatunde O OkesolaAlvaro Mata
Aug 5, 2021·Chemistry : a European Journal·Carmen C PirasDavid K Smith
Aug 3, 2021·Chemistry : a European Journal·Carmen C Piras, David K Smith

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