Commingling and segregation analysis of blood pressure in consanguineous and nonconsanguineous families from Andhra Pradesh, India

American Journal of Human Biology : the Official Journal of the Human Biology Council
A NirmalaD C Rao

Abstract

The hypothesis of a major gene effect for systolic blood pressure (SBP) and diastolic blood pressure (DBP) was examined in families from Andhra Pradesh, India, where consanguinity and marriage within caste are commonly practiced. The data were examined separately by noninbred versus complete (inbred + noninbred) families, both before and after correction for residual skewness. For SBP in the noninbred sample prior to skewness transformation, evidence consistent with a relatively common major recessive gene (q = 0.31) accounted for approximately 30% of the variance. In the combined sample, although Mendelian τs were rejected, the major gene estimates were similar to those in the noninbred data, and failure to account for inbreeding in the likelihood function may have influenced the results. After transformation of the data for residual skewness only a multifactorial component resulted, which accounted for about 80% (complete sample) and 100% (noninbred sample) of the offspring variance, and less than 10% of the parental variance. Even though the major gene effect disappeared after skewness transformation, the putative recessive major gene found for SBP prior to the transformation may be genuine since the tests on the transmissio...Continue Reading

References

Mar 1, 1987·American Journal of Medical Genetics·M L MarazitaC G Hames
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Citations

Dec 19, 2001·American Journal of Human Biology : the Official Journal of the Human Biology Council·A Nirmala
Jun 28, 1996·American Journal of Medical Genetics·G LivshitsD Brunner
Mar 3, 2005·Annals of Human Biology·M Sengupta, B Karmakar

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