Common and differential alterations of general emotion processing in obsessive-compulsive and social anxiety disorder

Psychological Medicine
Steffi WeidtA B Bruehl

Abstract

Obsessive compulsive disorder (OCD) and social anxiety disorder (SAD) are characterized by biased perception and processing of potentially threatening stimuli. A hyper-reactivity of the fear-circuit [e.g. amygdala, anterior cingulate (ACC)] has been consistently reported using functional magnetic resonance imaging (fMRI) in SAD in comparison with healthy controls (HCs). Studies investigating the processing of specific emotional stimuli in OCD reported mainly orbitofrontal-striatal abnormalities. The goal of this study was to examine similar/common and differential neurobiological responses in OCD and SAD using unspecific emotional stimuli. Fifty-four subjects participated: two groups (each n = 18) of outpatients with a current diagnosis of OCD or SAD, and 18 HCs. All subjects underwent fMRI while anticipating and perceiving unspecific visual stimuli with prior announced emotional valence (e.g. positive). Compared to HCs, the combined patient group showed increased activation in amygdala, caudate and prefrontal/orbitofrontal cortex while anticipating unspecific emotional stimuli. Caudate was more active in the combined patient group during perception. A comparison between the OCD and the SAD samples revealed increased amygdala a...Continue Reading

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Citations

May 26, 2017·Depression and Anxiety·Raoul DieterichNorbert Kathmann
Jun 15, 2016·International Journal of Adolescent Medicine and Health·Zohreh HalvaiepourMostafa Khanzadeh
Dec 24, 2020·Journal of Obsessive-compulsive and Related Disorders·Vahid KhosravaniSeyed Mehdi Samimi Ardestani
Feb 2, 2021·Human Brain Mapping·Lekai LuoQiyong Gong
Jan 9, 2021·Molecular Psychiatry·Elizabeth ShephardEuripedes C Miguel
Nov 17, 2020·Frontiers in Human Neuroscience·Koji KoizumiMasayuki Nakao

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