Common and differential pathophysiological features accompany comparable cognitive impairments in medication-free patients with schizophrenia and in healthy aging subjects.

Biological Psychiatry
Jean-Claude DreherK F Berman

Abstract

Dysfunction of the dorsolateral prefrontal cortex (DLPFC) and parahippocampal region along with poor working memory are common neurophysiological and behavioral features associated with schizophrenia and normal aging. It is, however, unknown whether the associated patterns of neural activation differ between these two groups when their cognitive performance is closely matched in a pairwise manner. The authors sought to pinpoint common and differential pathophysiological features that accompany comparable working memory impairments in schizophrenia and healthy aging. Fifty-three subjects were scanned with oxygen-15 water positron emission tomography regional cerebral blood flow measurements during working memory. Seventeen medication-free patients with schizophrenia were individually matched for working memory performance with 17 healthy aging subjects. Brain activation of the two index groups were compared with each other and with 19 young healthy individuals. Patients with schizophrenia showed right DLPFC hypoactivation, both when compared with age-matched control subjects and after direct comparison with working memory performance-matched elderly subjects. Moreover, both groups with working memory deficits shared an inability...Continue Reading

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Citations

Apr 18, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Arash NazeriAristotle N Voineskos
Mar 31, 2015·Annals of Clinical and Translational Neurology·Jennifer S YokoyamaDena B Dubal
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Oct 31, 2015·Journal of Attention Disorders·José SalavertEdith Pomarol-Clotet
Nov 5, 2019·Psychological Medicine·Marta Martin-SuberoEdith Pomarol-Clotet
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Mar 23, 2017·Scientific Reports·Romuald GirardJean-Claude Dreher
Dec 27, 2019·NeuroImage. Clinical·Paola Fuentes-ClaramonteRaymond Salvador

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