Common and Dissociable Dysfunction of the Reward System in Bipolar and Unipolar Depression

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Theodore D SatterthwaiteDaniel H Wolf

Abstract

Unipolar and bipolar depressive episodes have a similar clinical presentation that suggests common dysfunction of the brain's reward system. Here, we evaluated the relationship of both dimensional depression severity and diagnostic category to reward system function in both bipolar and unipolar depression. In total, 89 adults were included, including 27 with bipolar depression, 25 with unipolar depression, and 37 healthy comparison subjects. Subjects completed both a monetary reward task and a resting-state acquisition during 3T BOLD fMRI. Across disorders, depression severity was significantly associated with reduced activation for wins compared with losses in bilateral ventral striatum, anterior cingulate cortex, posterior cingulate cortex, and right anterior insula. Resting-state connectivity within this reward network was also diminished in proportion to depression severity, most notably connectivity strength in the left ventral striatum. In addition, there were categorical differences between patient groups: resting-state connectivity at multiple reward network nodes was higher in bipolar than in unipolar depression. Reduced reward system task activation and resting-state connectivity therefore appear to be a brain phenoty...Continue Reading

References

Jan 1, 1988·Journal of Psychiatric Research·R L Spitzer, J B Williams
Mar 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·K J FristonR Turner
Dec 1, 1996·Journal of Personality Assessment·A T BeckW Ranieri
Dec 9, 2000·Journal of Neurophysiology·M R DelgadoJ A Fiez
Jan 2, 2004·The American Journal of Psychiatry·S Nassir GhaemiRoss J Baldessarini
May 12, 2004·Neuron·Caroline F ZinkGregory S Berns
Feb 12, 2005·Biological Psychiatry·Diego A PizzagalliJames P O'Shea
Sep 6, 2005·NeuroImage·Georg JuckelAndreas Heinz
Sep 13, 2005·NeuroImage·Caroline F ZinkGregory S Berns
Aug 2, 2006·Current Psychiatry Reports·Daniel H Wolf
Jun 26, 2007·Brain : a Journal of Neurology·J D SteeleK P Ebmeier
Jul 28, 2007·Acta Psychiatrica Scandinavica·C L BowdenX Chang
Nov 8, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Birgit AblerStephan Heckers
Apr 25, 2008·Journal of Psychiatric Research·Diego A PizzagalliMaurizio Fava
Mar 6, 2009·Journal of Affective Disorders·Moria J SmoskiGabriel S Dichter
May 5, 2009·The American Journal of Psychiatry·Diego A PizzagalliMaurizio Fava
Jul 3, 2009·The American Journal of Psychiatry·Argyris StringarisEllen Leibenluft
Jul 4, 2009·NeuroImage·Douglas N Greve, Bruce Fischl
Sep 26, 2009·Neuron·Joseph W Kable, Paul W Glimcher
Oct 13, 2009·NeuroImage·Mikail Rubinov, Olaf Sporns
Jul 3, 2010·The American Journal of Psychiatry·Thomas InselPhilip Wang
Jul 7, 2010·Neuroscience and Biobehavioral Reviews·Michael T Treadway, David H Zald
Aug 7, 2010·Medical Image Analysis·Yangming OuChristos Davatzikos
Mar 3, 2011·The American Journal of Psychiatry·Jan PetersUNKNOWN IMAGEN Consortium
Oct 8, 2011·NeuroImage·Mark JenkinsonStephen M Smith
Mar 16, 2012·The American Journal of Psychiatry·Oliver J RobinsonWayne C Drevets
Apr 17, 2012·Neuroscience Letters·Chun-Hong LiuChuan-Yue Wang
May 29, 2012·Bipolar Disorders·Danella M HafemanMary L Phillips
Feb 26, 2013·Journal of Affective Disorders·William R MarchandJohn Thatcher
Mar 15, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nan LiDa-Ren Zhang
Apr 6, 2013·The American Journal of Psychiatry·Xavier CaserasMary L Phillips
May 25, 2013·Journal of the American Academy of Child and Adolescent Psychiatry·Vilma GabbayMichael P Milham
Oct 1, 2013·Social Cognitive and Affective Neuroscience·Daniel G DillonDiego A Pizzagalli

❮ Previous
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Citations

Feb 27, 2016·Journal of Affective Disorders·Rachel HershenbergDaniel H Wolf
Jul 28, 2016·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Henry W Chase, Mary L Phillips
Dec 9, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Leonhard Schilbach
Mar 26, 2016·Frontiers in Systems Neuroscience·Aaron S Heller
Nov 4, 2015·Current Behavioral Neuroscience Reports·Mitra Heshmati, Scott J Russo
May 18, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sarah TrostOliver Gruber
Aug 24, 2016·Journal of Psychiatric Research·Lisa M McTeagueAmit Etkin
Sep 16, 2016·Nature Reviews. Disease Primers·Christian OtteAlan F Schatzberg
Oct 5, 2016·Depression and Anxiety·Michelle G CraskeHalina J Dour
Oct 21, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Erin WalshGabriel S Dichter
Mar 11, 2017·Scientific Reports·Dongil ChungPearl H Chiu
Mar 10, 2018·Current Psychiatry Reports·Sakina J RizviSidney Kennedy
Jun 15, 2017·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Shokouh ArjmandMohammad Shabani
Jun 23, 2018·CNS Neuroscience & Therapeutics·Bao-Juan LiDe-Wen Hu
Jul 26, 2018·The European Journal of Neuroscience·Maria M DiehlDavid V Smith
Mar 7, 2018·CNS Neuroscience & Therapeutics·Fei-Fei ZhangQi-Yong Gong
Jan 3, 2019·Expert Review of Neurotherapeutics·Benedetta VaiFrancesco Benedetti
Feb 15, 2019·Expert Review of Neurotherapeutics·Trisha Chakrabarty, Lakshmi N Yatham
Feb 9, 2019·Psychiatry and Clinical Neurosciences·Tom Macpherson, Takatoshi Hikida
May 31, 2020·Cognitive, Affective & Behavioral Neuroscience·Alessandra BorsiniMatthew J Kempton
Aug 3, 2018·Nature Communications·Cedric Huchuan XiaTheodore D Satterthwaite
Aug 20, 2019·The European Journal of Neuroscience·Katarzyna A DudekCaroline Menard
Feb 27, 2020·Scientific Reports·Dahlia MukherjeeJoseph W Kable
Sep 3, 2019·Frontiers in Psychiatry·Alena DamborskáChristoph M Michel
May 28, 2020·The Australian and New Zealand Journal of Psychiatry·Yajing PangHuafu Chen
Apr 18, 2017·Annals of the New York Academy of Sciences·Sébastien HélieDan Foti
Mar 25, 2017·Social Cognitive and Affective Neuroscience·Katherine S DammeRobin Nusslock
Dec 16, 2017·Psychodynamic Psychiatry·Joanna Chambers
Feb 16, 2019·Frontiers in Psychiatry·Bing CaoRoger S McIntyre

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