Common and distinct mechanisms of induced pulmonary fibrosis by particulate and soluble chemical fibrogenic agents

Archives of Toxicology
Jie DongQiang Ma

Abstract

Pulmonary fibrosis results from the excessive deposition of collagen fibers and scarring in the lungs with or without an identifiable cause. The mechanism(s) underlying lung fibrosis development is poorly understood, and effective treatment is lacking. Here we compared mouse lung fibrosis induced by pulmonary exposure to prototypical particulate (crystalline silica) or soluble chemical (bleomycin or paraquat) fibrogenic agents to identify the underlying mechanisms. Young male C57BL/6J mice were given silica (2 mg), bleomycin (0.07 mg), or paraquat (0.02 mg) by pharyngeal aspiration. All treatments induced significant inflammatory infiltration and collagen deposition, manifesting fibrotic foci in silica-exposed lungs or diffuse fibrosis in bleomycin or paraquat-exposed lungs on day 7 post-exposure, at which time the lesions reached their peaks and represented a junction of transition from an acute response to chronic fibrosis. Lung genome-wide gene expression was analyzed, and differential gene expression was confirmed by quantitative RT-PCR, immunohistochemistry, and immunoblotting for representative genes to demonstrate their induced expression and localization in fibrotic lungs. Canonical signaling pathways, gene ontology, an...Continue Reading

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Citations

Nov 7, 2016·Particle and Fibre Toxicology·Jie Dong, Qiang Ma
Jul 12, 2017·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Rokhsana RasooliAli Mandegary
Oct 22, 2019·Cell Biology International·Karthika MuthuramalingamYoungmee Kim
Nov 17, 2019·Environmental Science and Pollution Research International·Sirus MirzaeeMohammad Javad Khodayar
Sep 18, 2020·The Journal of International Medical Research·Hai LiXiangdong Jian
Jul 16, 2020·Clinical & Translational Immunology·Andrew LucasMichaela Lucas
Jun 7, 2018·Frontiers in Immunology·Jie Dong, Qiang Ma
Oct 8, 2020·International Journal of Molecular Sciences·Dorothy J You, James C Bonner
Feb 23, 2021·Molecular Therapy. Methods & Clinical Development·Mitchel J R RuigrokWouter L J Hinrichs

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