Common and Rare Variants Genetic Association Analysis of Cigarettes per Day Among Ever-Smokers in Chronic Obstructive Pulmonary Disease Cases and Controls

Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco
Sharon M LutzECLIPSE and COPDGene Investigators

Abstract

Cigarette smoking is a major environmental risk factor for many diseases, including chronic obstructive pulmonary disease (COPD). There are shared genetic influences on cigarette smoking and COPD. Genetic risk factors for cigarette smoking in cohorts enriched for COPD are largely unknown. We performed genome-wide association analyses for average cigarettes per day (CPD) across the Genetic Epidemiology of COPD (COPDGene) non-Hispanic white (NHW) (n = 6659) and African American (AA) (n = 3260), GenKOLS (the Genetics of Chronic Obstructive Lung Disease) (n = 1671), and ECLIPSE (the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints) (n = 1942) cohorts. In addition, we performed exome array association analyses across the COPDGene NHW and AA cohorts. We considered analyses across the entire cohort and stratified by COPD case-control status. We identified genome-wide significant associations for CPD on chromosome 15q25 across all cohorts (lowest p = 1.78 × 10-15), except in the COPDGene AA cohort alone. Previously reported associations on chromosome 19 had suggestive and directionally consistent associations (RAB4, p = 1.95 × 10-6; CYP2A7, p = 7.50 × 10-5; CYP2B6, p = 4.04 × 10-4). When we stratified by COP...Continue Reading

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Citations

Mar 14, 2020·Genetic Epidemiology·Sharon M LutzChristoph Lange
May 22, 2019·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Andrew W BergenSean P David
Oct 14, 2020·Scientific Reports·Laura Florez-SampedroBarbro N Melgert
Oct 28, 2020·American Journal of Epidemiology·Woori KimTerri H Beaty
May 20, 2021·Genetic Epidemiology·Sharon M LutzChristoph Lange
Jul 6, 2021·Saudi Journal of Biological Sciences·Mikhlid H AlmutairiAbdelhabib Semlali

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