PMID: 640654Mar 17, 1978Paper

Common and uncommon immunoglobulin haplotypes among Lebanese communities

Human Genetics
Gérard LefrancE van Loghem

Abstract

Allotypes of IgG1, IgG2, IgG3, and IgA2 subclasses were investigated in seven Lebanese communities (three Moslem and four Christian). The Gm-Am haplotypes found were mainly those prevalent in Caucasians with a low frequency of haplotypes usually observed in Africans and Orientals. The difference between highlanders and lowlanders as expressed by G2m(23) was highly significant and suggested a possible adaptation to selective pressure related to the gamma2 genes, possibly due to endemic malaria in the past. Exceptional Gm-Am haplotypes were unambiguously determined by family studies. Some were characterized either by a deletion or a repression or, in contrast, by a partial or total duplication of gamma genes. Two others had uncommon combinations of allotypes: Gm17;23;5,10,11,13,14 A2m1, where G1m (17) was present without G1m (1); and Gm3;23;5,14 A2m1, where the CH3 allotypes G3m (10,11,13) were lacking.

Citations

Jan 1, 1981·Human Genetics·G LefrancJ Loiselet
Jan 1, 1979·Human Genetics·G LefrancE van Loghem
Sep 19, 1998·Annals of Human Biology·M P GiraldoJ M Dugoujon
Sep 25, 2010·Legal Medicine·Eliane ChoueryAndré Mégarbané
Dec 16, 2011·International Journal of Immunogenetics·M CapredonJ-M Dugoujon
Feb 27, 2008·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Sami El-ToumAhmed Feki
Aug 1, 1983·Journal of Immunogenetics·P YouinouC Salmon
Feb 1, 1982·Journal of Immunogenetics·G LefrancE van Loghem
Apr 26, 2020·International Journal of Environmental Research and Public Health·Han C G Kemper
Sep 4, 2020·Biomedicines·Marie-Paule Lefranc, Gérard Lefranc
Sep 1, 1979·Tissue Antigens·J L SerreA Jacquard
Jan 1, 1984·Zeitschrift für Rechtsmedizin. Journal of legal medicine·M Basler, J Henke

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