Common Bean Subtelomeres Are Hot Spots of Recombination and Favor Resistance Gene Evolution

Frontiers in Plant Science
Nicolas W G ChenValérie Geffroy

Abstract

Subtelomeres of most eukaryotes contain fast-evolving genes usually involved in adaptive processes. In common bean (Phaseolus vulgaris), the Co-2 anthracnose resistance (R) locus corresponds to a cluster of nucleotide-binding-site leucine-rich-repeat (NL) encoding sequences, the prevalent class of plant R genes. To study the recent evolution of this R gene cluster, we used a combination of sequence, genetic and cytogenetic comparative analyses between common bean genotypes from two distinct gene pools (Andean and Mesoamerican) that diverged 0.165 million years ago. Co-2 is a large subtelomeric cluster on chromosome 11 comprising from 32 (Mesoamerican) to 52 (Andean) NL sequences embedded within khipu satellite repeats. Since the recent split between Andean and Mesoamerican gene pools, the Co-2 cluster has experienced numerous gene-pool specific NL losses, leading to distinct NL repertoires. The high proportion of solo-LTR retrotransposons indicates that the Co-2 cluster is located in a hot spot of unequal intra-strand homologous recombination. Furthermore, we observe large segmental duplications involving both Non-Homologous End Joining and Homologous Recombination double-strand break repair pathways. Finally, the identificatio...Continue Reading

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Citations

Jan 28, 2020·PLoS Genetics·Eleanor YoungMing Xiao
Jun 12, 2019·PloS One·Juan ZhaoZhicheng Lin
Aug 8, 2020·Genome Génome / Conseil National De Recherches Canada·Sandra MendesAndrea Pedrosa-Harand
Apr 3, 2020·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Chuna KimJunho Lee
Jan 31, 2021·Nature Communications·Tatiana GarciaMaria Isabel Chacón-Sánchez
Feb 10, 2020·Journal of Molecular Biology·Marta Kwapisz, Antonin Morillon
May 5, 2021·Molecular Plant Pathology·Nicolas W G ChenMarie-Agnès Jacques
May 13, 2021·Nature Communications·Samira Mafi MoghaddamPhillip E McClean
Jun 25, 2021·Nucleic Acids Research·Frédéric Chaux-JukicZhou Xu
Aug 27, 2021·Frontiers in Genetics·Mostafa RahnamaMark L Farman
Aug 25, 2021·The Plant Journal : for Cell and Molecular Biology·Elisa BellucciRoberto Papa

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Datasets Mentioned

BETA
G19833
BAT93
FO9255992
FO681292
KP164990

Methods Mentioned

BETA
sulfotransferase

Software Mentioned

BLASTN
LTR
MAPMAKER
BLASTX
BLASTP
MAFFT
RDP
GeneMarkhmm
mVISTA
Bootscan

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