PMID: 12780797Jun 5, 2003Paper

Common cytological and cytogenetic features of Epstein-Barr virus (EBV)-positive natural killer (NK) cells and cell lines derived from patients with nasal T/NK-cell lymphomas, chronic active EBV infection and hydroa vacciniforme-like eruptions

British Journal of Haematology
Yu ZhangKohtaro Yamamoto

Abstract

In this study, we describe the cytological and cytogenetic features of six Epstein-Barr virus (EBV)-infected natural killer (NK) cell clones. Three cell clones, SNK-1, -3 and -6, were derived from patients with nasal T/NK-cell lymphomas; two cell clones, SNK-5 and -10, were isolated from patients with chronic active EBV infection (CAEBV); and the other cell clone, SNK-11, was from a patient with hydroa vacciniforme (HV)-like eruptions. An analysis of the number of EBV-terminal repeats showed that the SNK cell clones had monoclonal EBV genomes identical to the original EBV-infected cells of the respective patients, and SNK cells had the type II latency of EBV infection, suggesting that not only the cell clones isolated from nasal T/NK-cell lymphomas but also those isolated from CAEBV and HV-like eruptions had been transformed by EBV to a certain degree. Cytogenetic analysis detected deletions in chromosome 6q in five out of the six SNK cell clones, while 6q was not deleted in four control cell lines of T-cell lineage. This suggested that a 6q deletion is a characteristic feature of EBV-positive NK cells, which proliferated in the diseased individuals. The results showed that EBV-positive NK cells in malignant and non-malignant l...Continue Reading

References

Feb 11, 1992·The American Journal of Surgical Pathology·L M WeissH F Frierson
Jul 1, 1989·The Journal of Clinical Investigation·K Kawa-HaK Hirai
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·Y TakiharaT W Mak
Nov 1, 1986·Archives of Dermatology·T OonoY Ohtsuki
Jan 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·G HenleV Diehl
May 1, 1982·Lancet·D C Doll, A F List
Sep 18, 1982·Lancet·J L ZieglerK Yamamoto
Jan 1, 1995·Journal of the American Academy of Dermatology·R Ruiz-MaldonadoC Duran McKinster
Feb 1, 1995·Journal of the American Academy of Dermatology·N TabataH Tagami
Aug 1, 1994·Journal of the American Academy of Dermatology·H AsadaK Yoshikawa
Sep 1, 1994·The American Journal of Surgical Pathology·J K ChanV W Ma
Jan 1, 1996·Journal of Clinical Pathology·J van GorpC J Meijer
Nov 4, 1996·International Journal of Cancer. Journal International Du Cancer·A K ChiangF C Ho
Jun 11, 1997·International Journal of Cancer. Journal International Du Cancer·K OhshimaM Kikuchi
Nov 14, 1997·International Journal of Cancer. Journal International Du Cancer·A K ChiangF C Ho
May 15, 1998·Journal of the American Academy of Dermatology·M MagañaO P Sangüeza
Feb 20, 1999·Journal of the American Academy of Dermatology·K IwatsukiF Kaneko

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Citations

Dec 30, 2006·Der Pathologe·T RüdigerH K Müller-Hermelink
Sep 18, 2012·Current Hematologic Malignancy Reports·Lindsay C GeorgeChristopher P Fox
Jun 12, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J I CohenE S Jaffe
May 21, 2013·The Journal of Infectious Diseases·Yoshihiko KawanoYoshinori Ito
Nov 22, 2013·The American Journal of Dermatopathology·Angel Fernandez-Flores
Nov 26, 2010·The American Journal of Surgical Pathology·Socorro Maria Rodríguez-PinillaMiguel A Piris
Dec 21, 2013·Pathology, Research and Practice·Tiantian ZhangQiongli Zhai
Dec 17, 2008·Clinical Lymphoma & Myeloma·Claudiu V Cotta, Eric D Hsi
Sep 18, 2007·Journal of Virological Methods·Naomi KubotaHiroshi Kimura
Dec 16, 2006·Pediatrics International : Official Journal of the Japan Pediatric Society·Yuya SatoMitsuoki Eguchi
Dec 21, 2010·International Journal of Cancer. Journal International Du Cancer·Seiko IwataHiroshi Kimura
Apr 19, 2015·Journal of Experimental & Clinical Cancer Research : CR·Ting WuXuanyi Wang
Apr 9, 2015·British Journal of Haematology·John T Sandlund, Sherrie L Perkins
Mar 22, 2015·The American Journal of Pathology·Can KüçükWing C Chan
Jul 30, 2014·Journal of Pediatric Hematology/oncology·Deepthi BodduLeni G Mathew
Feb 2, 2008·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Bill H ChangGuang Fan
Jan 31, 2018·Genes, Chromosomes & Cancer·Hyein AhnJin Ho Paik
Mar 10, 2018·Cancer Medicine·Jun-Ichi KawadaHiroshi Kimura

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