Common defects of mitochondria and iron in neurodegeneration and diabetes (MIND): a paradigm worth exploring

Biochemical Pharmacology
Matthew StrohHao Zhu

Abstract

A popular, if not centric, approach to the study of an event is to first consider that of the simplest cause. When dissecting the underlying mechanisms governing idiopathic diseases, this generally takes the form of an ab initio genetic approach. To date, this genetic 'smoking gun' has remained elusive in diabetes mellitus and for many affected by neurodegenerative diseases. With no single gene, or even subset of genes, conclusively causative in all cases, other approaches to the etiology and treatment of these diseases seem reasonable, including the correlation of a systems' predisposed sensitivity to particular influence. In the cases of diabetes mellitus and neurodegenerative diseases, overlapping themes of mitochondrial influence or dysfunction and iron dyshomeostasis are apparent and relatively consistent. This mini-review discusses the influence of mitochondrial function and iron homeostasis on diabetes mellitus and neurodegenerative disease, namely Alzheimer's disease. Also discussed is the incidence of diabetes accompanied by neuropathy and neurodegeneration along with neurodegenerative disorders prone to development of diabetes. Mouse models containing multiple facets of this overlap are also described alongside curren...Continue Reading

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Mar 16, 2016·Metabolism: Clinical and Experimental·Petra BaumMarcin Nowicki
Apr 20, 2019·SAGE Open Medical Case Reports·Miyako KishimotoKazushige Washizaki
Aug 4, 2020·Biochimica Et Biophysica Acta. Molecular Cell Research·Rachel NechushtaiRon Mittler

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