Common effects of attractive and repulsive signaling: Further analysis of Mical-mediated F-actin disassembly and regulation by Abl

Communicative & Integrative Biology
Jimok Yoon, Jonathan R Terman

Abstract

To change their size, shape, and connectivity, cells require actin and tubulin proteins to assemble together into long polymers - and numerous extracellular stimuli have now been identified that alter the assembly and organization of these cytoskeletal structures. Yet, there remains a lack of defined signaling pathways from the cell surface to the cytoskeleton for many of these extracellular signals, and so we still know little of how they exert their precise structural effects. These extracellular cues may be soluble or substrate-bound and have historically been classified into two independently acting and antagonistic groups: growth-promoting/attractants (inducing turning toward the source of the factor/positive chemotropism) or growth-preventing/repellents (turning away from the source of the factor/negative chemotropism). Paradoxically, our recent results directly link the action of growth factors/chemoattractants and their signaling pathways to the promotion of the disassembly of the F-actin cytoskeleton (a defined readout of repellents/repulsive signaling). Herein, we add to this by simply driving a constitutively active form of Mical, which strongly disassembles F-actin/remodels cells in vivo independent of repulsive cue...Continue Reading

References

Feb 27, 1999·Current Opinion in Cell Biology·J D Sutherland, W Witke
Dec 17, 2005·Proceedings of the National Academy of Sciences of the United States of America·Lewis G Tilney, David J DeRosier
Aug 16, 2008·The European Journal of Neuroscience·Staci D SanfordKarl H Pfenninger
Feb 12, 2010·Nature·Ruei-Jiun HungJonathan R Terman
May 11, 2010·Cold Spring Harbor Perspectives in Biology·Greg J Bashaw, Rüdiger Klein
Jun 30, 2010·Molecular and Cellular Neurosciences·Sibel NaskaDavid R Kaplan
Aug 19, 2010·The EMBO Journal·Anastacia Berzat, Alan Hall
Nov 26, 2010·Cold Spring Harbor Perspectives in Biology·Erik W DentFrank B Gertler
Dec 3, 2010·Cold Spring Harbor Perspectives in Biology·Alex L Kolodkin, Marc Tessier-Lavigne
Oct 1, 2011·Anthropologischer Anzeiger; Bericht über die biologisch-anthropologische Literatur·George R Milner, Rebecca J Ferrell
Nov 26, 2011·Science·Ruei-Jiun HungJonathan R Terman
Dec 14, 2011·Science Signaling·Katrin DeinhardtBarbara L Hempstead
Nov 12, 2013·Nature Cell Biology·Ruei-Jiun HungJonathan R Terman
Jan 15, 2014·Molecular and Cellular Biology·Jean Y J Wang
Jan 6, 2016·Journal of Cell Science·Aaditya KhatriAnn Marie Pendergast
Mar 6, 2016·Journal of Cell Science·Naoya YamashitaYoshio Goshima
Mar 19, 2016·Cold Spring Harbor Perspectives in Biology·Thomas D Pollard
Oct 19, 2016·Cytoskeleton·Carlos WilsonGiasuddin Ahmed
Jul 28, 2016·Nature Cell Biology·Elena E GrintsevichEmil Reisler
Oct 28, 2016·Methods in Molecular Biology·Laura Taylor Alto, Jonathan R Terman
Feb 24, 2017·Free Radical Biology & Medicine·Bruno Manta, Vadim N Gladyshev
Jun 13, 2017·Archives of Biochemistry and Biophysics·Maria Antonietta Vanoni
Jul 12, 2017·Developmental Cell·Jimok YoonJonathan R Terman
Jul 26, 2017·Developmental Cell·Dietmar Schmucker

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Citations

Feb 1, 2020·Seminars in Cell & Developmental Biology·Anna S Kashina

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Methods Mentioned

BETA
transgenic

Software Mentioned

Mical redoxCH
Microsoft Office Powerpoint
Extended Focus
Mical
Zeiss Axiovision

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