Common extracellular matrix regulation of myeloid cell activity in the bone marrow and tumor microenvironments

Cancer Immunology, Immunotherapy : CII
Sabina SangalettiMario P Colombo

Abstract

The complex interaction between cells undergoing transformation and the various stromal and immunological cell components of the tumor microenvironment (TME) crucially influences cancer progression and diversification, as well as endowing clinical and prognostic significance. The immunosuppression characterizing the TME depends on the recruitment and activation of different cell types including regulatory T cells, myeloid-derived suppressor cells, and tumor-associated macrophages. Less considered is the non-cellular component of the TME. Here, we focus on the extracellular matrix (ECM) regulatory activities that, within the TME, actively contribute to many aspects of tumor progression, acting on both tumor and immune cells. Particularly, ECM-mediated regulation of tumor-associated immunosuppression occurs through the modulation of myeloid cell expansion, localization, and functional activities. Such regulation is not limited to the TME but occurs also within the bone marrow, wherein matricellular proteins contribute to the maintenance of specialized hematopoietic stem cell niches thereby regulating their homeostasis as well as the generation and expansion of myeloid cells under both physiological and pathological conditions. Hi...Continue Reading

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Citations

Feb 27, 2020·Cellular and Molecular Life Sciences : CMLS·Henrik J JürgensenDaniel H Madsen
Mar 15, 2019·Journal for Immunotherapy of Cancer·Dorota E KuczekDaniel H Madsen
Jul 10, 2019·Frontiers in Immunology·Sabina SangalettiMario P Colombo
Feb 23, 2019·Frontiers in Immunology·Yungang WangShengjun Wang
Jan 12, 2021·Journal of Cell Communication and Signaling·Roos J LeguitRoel Goldschmeding
Dec 16, 2019·Ageing Research Reviews·Antero Salminen
Feb 23, 2021·Molecular Therapy Oncolytics·Yixiao QinYongyan Wu
Jun 3, 2021·International Journal of Molecular Sciences·Elise AasebøØystein Bruserud
Aug 25, 2021·Cancer Immunology Research·Kevin J PaavolaJer-Yuan Hsu
Apr 10, 2020·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Claudio Tripodo

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