Common genetic mechanisms in alcoholism and psychiatric disorders: negative evidence from a study of ethnic group patients

Alcoholism, Clinical and Experimental Research
J Galdi, R R Bonato

Abstract

Alcoholism in the male relatives of patients with various (nonalcoholic) psychiatric disorders is consistently elevated above population risk. Over the years, this finding has given rise to theories which propose that some forms of alcoholism are attributable to the pleiotropic expression of genes underlying these disorders. This mechanism was tested in the fathers of patients from ethnic groups associated with culturally suppressed alcohol abuse where it was predicted that decreased alcoholism would be substituted for by increased psychiatric disorder. Results, however, failed to support such a mechanism. Other explanations of this elevated alcoholism were considered.

References

Jul 1, 1975·Journal of Studies on Alcohol·E X Freed
Mar 1, 1975·The Journal of Nervous and Mental Disease·J R Morrison
Mar 1, 1975·Acta Psychiatrica Scandinavica·R C FowlerE Monnelly
Jul 1, 1971·The British Journal of Psychiatry : the Journal of Mental Science·R A WoodruffP J Clayton
Jun 1, 1974·The American Journal of Psychiatry·J R Morrison
Mar 1, 1973·Comprehensive Psychiatry·G WinokurR Crowe
Jul 1, 1973·The British Journal of Psychiatry : the Journal of Mental Science·K A Halmi, J Loney
Jan 1, 1974·The American Journal of Psychiatry·L H ReichJ M Himmelhoch
Mar 1, 1972·Comprehensive Psychiatry·R A WoodruffP J Clayton
Apr 1, 1969·The American Journal of Psychiatry·T ReichG Winokur
Dec 1, 1971·Archives of General Psychiatry·D W Goodwin
Aug 1, 1970·Archives of General Psychiatry·G WinokurF N Pitts
Feb 1, 1971·Archives of General Psychiatry·G WinokurM Baker
Feb 1, 1968·The British Journal of Psychiatry : the Journal of Mental Science·P I Woerner, S B Guze
Mar 1, 1969·Archives of General Psychiatry·M SchuckitG Winokur
Apr 1, 1967·Comprehensive Psychiatry·C C Jew, S A Brody
Jan 1, 1958·Acta psychiatrica et neurologica Scandinavica·J WELNER, E STROMGREN
Jan 1, 1961·Archiv für Psychiatrie und Nervenkrankheiten, vereinigt mit Zeitschrift für die gesamte Neurologie und Psychiatrie·K ROHR
Jan 1, 1950·Archiv für Psychiatrie und Nervenkrankheiten, vereinigt mit Zeitschrift für die gesamte Neurologie und Psychiatrie·A W WITTERMANS, B SCHULZ

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Citations

Apr 1, 1997·Acta Neurologica Scandinavica·M E ZöllerL Bäckman
Jul 1, 1985·American Journal of Medical Genetics·H M Mendez
Nov 29, 2005·Physiological Measurement·Vivek Nigam, Roland Priemer
Jan 1, 1981·British Journal of Addiction·D Dass

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