Common genetic variants in fatty acid-binding protein-4 (FABP4) and clinical diabetes risk in the Women's Health Initiative Observational Study.

Obesity
Kei-Hang K ChanSimin Liu

Abstract

Adipocypte fatty acid-binding protein-4 (FABP4/adipocyte P2) may play a central role in energy metabolism and inflammation. In animal models, defects of the aP2 gene (aP2(-/-)) partially protected against the development of obesity-related insulin resistance, dyslipidemia, and atherosclerosis. However, it is unclear whether common genetic variation in FABP4 gene contributes to risk of type 2 diabetes (T2D) or diabetes-related metabolic traits in humans. We comprehensively assess the genetic associations of variants in the FABP4 gene with T2D risk and diabetes-associated biomarkers in a prospective study of 1,529 cases and 2,147 controls among postmenopausal women aged 50-79 years who enrolled in the Women's Health Initiative Observational Study (WHI-OS). We selected and genotyped a total of 11 haplotype-tagging single-nucleotide polymorphisms (tSNPs) spanning 41.3 kb across FABP4 in all samples. None of the SNPs and their derived haplotypes showed significant association with T2D risk. There were no significant associations between SNPs and plasma levels of inflammatory and endothelial biomarkers, including C-reactive protein, tumor necrosis factor (TNF), interleukin-6 (IL-6), E-selectin, and intercellular adhesion molecule (IC...Continue Reading

References

Sep 30, 1994·Science·E S Lander, N J Schork
Aug 31, 2000·Endocrinology·K T UysalG S Hotamisligil
Mar 14, 2002·Current Opinion in Lipidology·Jeffrey B BoordMacRae F Linton
May 25, 2002·Science·Stacey B GabrielDavid Altshuler
Oct 25, 2003·Annals of Epidemiology·Garnet L AndersonRoss L Prentice
Aug 7, 2004·Bioinformatics·J C BarrettM J Daly
Jan 29, 2005·International Journal of Cardiology·Mary S BoulbouAnastasios E Germenis
May 3, 2005·The Journal of Clinical Investigation·Kathryn E Wellen, Gökhan S Hotamisligil
Sep 9, 2005·Current Opinion in Lipidology·Liza Makowski, Gökhan S Hotamisligil
Oct 26, 2005·Nature Genetics·Paul I W de BakkerDavid Altshuler
Oct 29, 2005·Nature·UNKNOWN International HapMap Consortium
Apr 28, 2006·Proceedings of the National Academy of Sciences of the United States of America·G TuncmanG S Hotamisligil
Aug 22, 2006·European Journal of Clinical Investigation·D Stejskal, M Karpisek
May 19, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·D C Y YeungK S L Lam
May 31, 2008·Nature Reviews. Drug Discovery·Masato Furuhashi, Gökhan S Hotamisligil

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Citations

Sep 21, 2012·Climacteric : the Journal of the International Menopause Society·G CamilleriJ Calleja-Agius
Jul 5, 2015·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·D IbarretxeL Masana
Feb 4, 2011·Diabetes Research and Clinical Practice·Liming BuMarino De Leon

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