Common genetic variation in the DKK1 gene is associated with hip axis length but not with bone mineral density and bone turnover markers in young adult men: results from the Odense Androgen Study

Calcified Tissue International
Elke PitersWim Van Hul

Abstract

LRP5 was recently confirmed as an important susceptibility gene for osteoporosis. Our objective was to evaluate the effect of DKK1 polymorphisms on bone mineral density (BMD), hip geometry, and bone turnover. DKK1 is a secreted protein that binds to LRP5/6 receptors and inhibits canonical Wnt signaling. Using HapMap, we selected three SNPs covering the genetic variation in a 13.53-kb region comprising DKK1. The Odense Androgen Study is a population-based study comprising 783 Caucasian men aged 20-29 years. BMD and hip structural parameters were available for study. Bone turnover markers were used as a secondary end point. All analyses were repeated after adjusting for covariables and in subgroups according to physical activity. We found no significant association between DKK1 and BMD or markers of bone turnover; however, a significant association (P = 0.012) was found for rs1569198 with hip axis length (HAL), independent of BMD and height. Moreover, the association seemed to be driven by the non-sedentary subgroup (P = 0.004). Haplotype analysis further confirmed the association of rs1569198 with HAL. Furthermore, we obtained indications for interaction between DKK1 and LRP5 genotypes for different hip geometry parameters. As a...Continue Reading

References

Jan 1, 1996·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P Geusens
Apr 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·N K ArdenT D Spector
Oct 23, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D B Burr
Nov 5, 1998·Journal of Biomechanics·G N DudaL Claes
Dec 29, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T J BeckH W Wahner
Jun 8, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T J BeckS R Cummings
Jun 19, 2001·American Journal of Human Genetics·J K Pritchard
Oct 16, 2001·The Journal of Clinical Endocrinology and Metabolism·E Seeman
May 25, 2002·Science·Stacey B GabrielDavid Altshuler
Jun 7, 2002·Endocrine Reviews·Munro PeacockTatiana Foroud
Sep 28, 2002·Human Molecular Genetics·Jonathan K Pritchard, Nancy J Cox
Dec 26, 2003·The New England Journal of Medicine·Erming TianJohn D Shaughnessy
Mar 26, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Paul GerdhemKarl J Obrant
Apr 28, 2004·Biochemical and Biophysical Research Communications·Keizo OhnakaRyoichi Takayanagi
May 15, 2004·Molecular and Cellular Biology·Yazhou ZhangDianqing Wu
Jun 1, 2004·Nature Reviews. Genetics·Franco Pagani, Francisco E Baralle
Jun 23, 2004·Bone·M P AkhterR R Recker
Aug 7, 2004·Bioinformatics·J C BarrettM J Daly
Feb 22, 2005·Biochemical and Biophysical Research Communications·Keizo OhnakaRyoichi Takayanagi
Mar 15, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Christian MeierJohn A Eisman
Jun 9, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Julie R HensJohn J Wysolmerski
Jul 23, 2005·Current Osteoporosis Reports·Rhonda A Brownbill, Jasminka Z Ilich
Sep 29, 2005·The Journal of Clinical Endocrinology and Metabolism·Jessica C GardnerSocrates E Papapoulos
Jan 19, 2006·International Journal of Obesity : Journal of the International Association for the Study of Obesity·T L NielsenC Hagen
Feb 1, 2006·Journal of Cellular Biochemistry·Christopher L HallEvan T Keller
Jun 7, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Frederic MorvanGeorges Rawadi
Aug 16, 2006·The Journal of Biological Chemistry·John A RobinsonFrederick J Bex
Feb 10, 2007·Rheumatic Diseases Clinics of North America·Elaine DennisonCyrus Cooper
Feb 14, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Wendy BalemansWim Van Hul
Mar 16, 2007·American Journal of Human Genetics·Gregory V KryukovShamil R Sunyaev
Apr 17, 2007·Cancer Treatment Reviews·N Voorzanger-Rousselot, P Garnero
Jul 7, 2007·Bone·Bryan T MacDonaldPeter V Hauschka
Sep 19, 2007·British Journal of Cancer·N Voorzanger-RousselotP Garnero
Oct 16, 2007·BMC Medical Genetics·Douglas P KielDavid Karasik

❮ Previous
Next ❯

Citations

May 7, 2015·BioMed Research International·Garima SharmaJu-Suk Nam
Feb 26, 2013·Seminars in Arthritis and Rheumatism·Eveline BoudinWim Van Hul
Sep 28, 2013·Clinical Chemistry and Laboratory Medicine : CCLM·Alireza MorovatEtienne Cavalier
Jul 22, 2018·Scientific Reports·Núria Martínez-GilSusana Balcells

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.