Common Genetic Variation Indicates Separate Causes for Periventricular and Deep White Matter Hyperintensities.

Stroke; a Journal of Cerebral Circulation
Nicola J ArmstrongPaul Nyquist

Abstract

Periventricular white matter hyperintensities (WMH; PVWMH) and deep WMH (DWMH) are regional classifications of WMH and reflect proposed differences in cause. In the first study, to date, we undertook genome-wide association analyses of DWMH and PVWMH to show that these phenotypes have different genetic underpinnings. Participants were aged 45 years and older, free of stroke and dementia. We conducted genome-wide association analyses of PVWMH and DWMH in 26,654 participants from CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology), ENIGMA (Enhancing Neuro-Imaging Genetics Through Meta-Analysis), and the UKB (UK Biobank). Regional correlations were investigated using the genome-wide association analyses -pairwise method. Cross-trait genetic correlations between PVWMH, DWMH, stroke, and dementia were estimated using LDSC. In the discovery and replication analysis, for PVWMH only, we found associations on chromosomes 2 (NBEAL), 10q23.1 (TSPAN14/FAM231A), and 10q24.33 (SH3PXD2A). In the much larger combined meta-analysis of all cohorts, we identified ten significant regions for PVWMH: chromosomes 2 (3 regions), 6, 7, 10 (2 regions), 13, 16, and 17q23.1. New loci of interest include 7q36.1 (NOS3) and 16q24.2. In both...Continue Reading

References

Aug 16, 2000·Proceedings of the National Academy of Sciences of the United States of America·H OsugaD S Park
Mar 28, 2003·The New England Journal of Medicine·Sarah E VermeerMonique M B Breteler
Apr 12, 2003·Stroke; a Journal of Cerebral Circulation·Sarah E VermeerUNKNOWN Rotterdam Scan Study
Mar 11, 2005·Neurochemical Research·Yanjie LuRajendra K Sharma
Apr 22, 2006·Stroke; a Journal of Cerebral Circulation·Malee S FernandoUNKNOWN MRC Cognitive Function and Ageing Neuropathology Study Group
Sep 7, 2006·International Journal of Geriatric Psychiatry·Mani S KrishnanUNKNOWN LADIS Group
Apr 3, 2008·Current Opinion in Psychiatry·Perminder SachdevWei Wen
Nov 21, 2009·Stroke; a Journal of Cerebral Circulation·Rebecca F GottesmanThomas H Mosley
Jul 10, 2010·Bioinformatics·Cristen J WillerGonçalo R Abecasis
Oct 12, 2010·Journal of Neurology, Neurosurgery, and Psychiatry·Alida A GouwJeroen J G Geurts
Jun 18, 2011·Annals of Neurology·Myriam FornageLenore J Launer
Aug 27, 2011·Stroke; a Journal of Cerebral Circulation·Benjamin F J VerhaarenM Arfan Ikram
Jan 3, 2012·American Journal of Human Genetics·Marion JeanneDouglas B Gould
Feb 16, 2012·European Journal of Human Genetics : EJHG·Elly VerbeekGrazia M S Mancini
Apr 23, 2013·Lancet Neurology·Joanna M WardlawMartin Dichgans
May 23, 2013·International Journal of Stroke : Official Journal of the International Stroke Society·Gillian M PotterJoanna M Wardlaw
Jul 11, 2013·Cerebrovascular Diseases·Stefan H KreiselMichael G Hennerici
Jul 23, 2013·Lancet Neurology·Joanna M WardlawUNKNOWN STandards for ReportIng Vascular changes on nEuroimaging (STRIVE v1)
Oct 26, 2014·Journal of Inherited Metabolic Disease·Inge TimmersM Estela Rubio-Gozalbo
Feb 3, 2015·Nature Genetics·Brendan K Bulik-SullivanBenjamin M Neale
Feb 6, 2015·Neurology·Kristiina RannikmäeUNKNOWN International Stroke Genetics Consortium
Feb 11, 2015·Circulation. Cardiovascular Genetics·Benjamin F J VerhaarenMyriam Fornage
Dec 18, 2015·Neurology·Matthew TraylorUNKNOWN International Stroke Genetics Consortium
May 5, 2016·European Journal of Human Genetics : EJHG·Matthew Traylor, Cathryn M Lewis
May 18, 2016·Nature Genetics·Joseph K PickrellDavid A Hinds
Dec 21, 2016·Annals of Neurology·Matthew TraylorUNKNOWN International Stroke Genetics Consortium
Apr 11, 2017·The Journal of Clinical Investigation·Philipp S WildMarcus Dörr
May 24, 2017·The Journal of Investigative Dermatology·Cristina Has
Jul 9, 2017·Biochemical Society Transactions·Julien Saint-PolEric Rubinstein
Sep 29, 2017·Neurology·Kristiina RannikmäeUNKNOWN Stroke Genetics Network (SiGN), METASTROKE Collaboration, and International Stroke Genetics Consortium (ISGC)
Oct 11, 2017·Stroke and Vascular Neurology·Pablo J BlancoJ David Spence
May 13, 2018·Stroke; a Journal of Cerebral Circulation·Loes C A Rutten-JacobsMatthew Traylor
Jun 13, 2018·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Chinthasagar BastianSelva Baltan
Jul 14, 2018·Stroke; a Journal of Cerebral Circulation·Xueqiu JianUNKNOWN neuroCHARGE Working Group
Nov 2, 2018·Annals of Neurology·Rainer MalikUNKNOWN MEGASTROKE consortium and the International Stroke Genetics Consortium
Jan 20, 2019·Neurology·Matthew TraylorUNKNOWN International Stroke Genetics Consortium

❮ Previous
Next ❯

Citations

Sep 13, 2020·Journal of Neurology, Neurosurgery, and Psychiatry·Audrey LowJohn T O'Brien
Oct 25, 2020·Acta Neuropathologica·Brittney L BlevinsPeter T Nelson
Nov 6, 2020·Stroke; a Journal of Cerebral Circulation·Jiang LiChristoph J Griessenauer
Dec 15, 2020·Human Brain Mapping·Melis AnatürkAnn-Marie G de Lange
Jan 8, 2021·Stroke; a Journal of Cerebral Circulation·Keun-Hwa JungDavid H Salat
Dec 21, 2020·Journal of the Neurological Sciences·Lars B HindenesTorgil R Vangberg
Mar 5, 2021·Stroke; a Journal of Cerebral Circulation·Grégoire PinVincent Planche
May 19, 2021·Stroke; a Journal of Cerebral Circulation·Michelle C JohansenPaul Nyquist
Jun 13, 2021·European Radiology·Santiago Medrano-MartorellEva Giralt-Steinhauer
Jul 27, 2021·Annals of Clinical and Translational Neurology·Hailing LiuQing Wang
Jul 30, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Antoine Garnier-CrussardGaël Chételat
Oct 9, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Rachana TankDonald M Lyall
Oct 10, 2021·Brain : a Journal of Neurology·Rainer MalikMartin Dichgans
Oct 24, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Chao DongWei Wen
Jan 11, 2022·Stroke; a Journal of Cerebral Circulation·Rebecca F Gottesman, Sudha Seshadri

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Epidemiology of Aging

This feed focuses on epidemiology of aging and aging-related conditions, including Alzheimer’s disease, dementia, and age-associated cognitive impairment. Here is the latest research.

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Related Papers

Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging
Nandakumar NagarajaMehmet S Albayram
Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Lei YangWenli Hu
Neurology
Michael MarnaneAlzheimer's Disease Neuroimaging Initiative
© 2022 Meta ULC. All rights reserved