PMID: 9194755Jun 1, 1997Paper

Common genomic variants associated with variation in plasma lipoproteins in young aboriginal Canadians

Arteriosclerosis, Thrombosis, and Vascular Biology
R A HegeleB Zinman

Abstract

We hypothesized that common genomic variants would be associated with variation in lipoprotein phenotypes in young subjects. We determined genotypes of FABP2, PON, APOC3, and APOE in 188 aboriginal Canadians, aged 9 to 17 years. We found that 13 of 32 possible genotype-phenotype associations were significant: (1) the FABP2 codon 54 genotype was associated with variation in plasma triglycerides (P = .045); (2) the PON codon 192 genotype was associated with variation in plasma total and LDL cholesterol and apoB (P = .0099, P = .0088, and P = .016, respectively); (3) the APOC3 insulin-response-element genotype was associated with variation in plasma triglycerides, HDL cholesterol, apoA-I, the total cholesterol to HDL cholesterol ratio, and the apoB to apoA-I ratio (P = .0014, P = .0069, P = .045, P = .0021, and P = .0081, respectively); and (4) the APOE restriction isotype was associated with variation in plasma LDL cholesterol, apoB, the total cholesterol to HDL cholesterol ratio, and the apoB to apoA-I ratio (P = .025, P = .034, P = .045, and P = .047, respectively). The average young age and relative absence of age-dependent secondary environmental factors could have eased the identification of small genetic effects on lipoprot...Continue Reading

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Citations

Dec 21, 2000·Current Atherosclerosis Reports·J M Ordovas, J R Galluzzi
May 5, 2005·Atherosclerosis·Rebecca L PollexRobert A Hegele
Oct 8, 1999·Clinica Chimica Acta; International Journal of Clinical Chemistry·R A Hegele
May 3, 2003·Clinical Biochemistry·Robert A HegeleHenian Cao
Jun 28, 2001·Atherosclerosis·M GroenendijkG M Dallinga-Thie
Aug 14, 1998·General Pharmacology·B MacknessM I Mackness
Jul 12, 2003·Molecular Genetics and Metabolism·Natalia L DuarteDavid E L Wilcken
Dec 15, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·F HamanM A Robidoux
Jun 15, 2007·Journal of Toxicology and Environmental Health. Part a·Farideh SepahvandMassoud Mahmoudian
Feb 24, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·S V AnisimovE I Schwartz
Jan 16, 2002·Cardiology in Review·Jacques Genest
Aug 22, 2000·Clinical Chemistry and Laboratory Medicine : CCLM·S FanellaR A Hegele
Dec 22, 2007·Atherosclerosis·Thomas M van HimbergenAnton F H Stalenhoef
Jun 26, 2001·European Journal of Clinical Investigation·K C ChiuC Yoon
Aug 20, 2010·American Journal of Human Biology : the Official Journal of the Human Biology Council·Sarinnapha VasunilashornCaleb E Finch
Jul 10, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·J DallongevilleN Helbecque
Nov 9, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·R L PollexR A Hegele
Nov 10, 2006·Annals of Human Biology·P P SinghS S Mastana
Jul 3, 1999·Nutrition Reviews·R A Hegele
Aug 12, 1999·Annals of Medicine·R A Hegele
Feb 16, 2008·International Journal of Circumpolar Health·Piya LahiryRobert A Hegele
Aug 9, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Robert A Hegele, Jacqueline S Dron
Mar 24, 2010·Cancer Epidemiology·Ikuko KatoRichard K Severson

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