Common HTR2A variants and 5-HTTLPR are not associated with human in vivo serotonin 2A receptor levels

Human Brain Mapping
Marie SpiesPatrick MacDonald Fisher

Abstract

The serotonin 2A receptor (5-HT2AR) is implicated in the pathophysiology and treatment of various psychiatric disorders. [18 F]altanserin and [11 C]Cimbi-36 positron emission tomography (PET) allow for high-resolution imaging of 5-HT2AR in the living human brain. Cerebral 5-HT2AR binding is strongly genetically determined, though the impact of specific variants is poorly understood. Candidate gene studies suggest that HTR2A single nucleotide polymorphisms including rs6311/rs6313, rs6314, and rs7997012 may influence risk for psychiatric disorders and mediate treatment response. Although known to impact in vitro expression of 5-HT2AR or other serotonin (5-HT) proteins, their effect on human in vivo brain 5-HT2AR binding has as of yet been insufficiently studied. We thus assessed the extent to which these variants and the commonly studied 5-HTTLPR predict neocortex in vivo 5-HT2AR binding in healthy adult humans. We used linear regression analyses and likelihood ratio tests in 197 subjects scanned with [18 F]altanserin or [11 C]Cimbi-36 PET. Although we observed genotype group differences in 5-HT2AR binding of up to ~10%, no genetic variants were statistically significantly predictive of 5-HT2AR binding in what is the largest huma...Continue Reading

References

Jul 1, 1992·Journal of Computer Assisted Tomography·R P WoodsJ C Mazziotta
Jun 24, 1999·The Journal of Comparative Neurology·V Cornea-HébertL Descarries
Aug 7, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Lars H PinborgGitte M Knudsen
Sep 10, 2004·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Lars H PinborgGitte M Knudsen
Sep 15, 2004·Biological Psychiatry·Michael J ParsonsAndrew J Makoff
Apr 2, 2005·The International Journal of Neuropsychopharmacology·Karen H AdamsGitte M Knudsen
Sep 28, 2005·Anatomy and Embryology·René HurlemannAndreas Bauer
Apr 28, 2006·American Journal of Human Genetics·Francis J McMahonHusseini Manji
Apr 28, 2006·American Journal of Human Genetics·Xian-Zhang HuDavid Goldman
Sep 2, 2006·The International Journal of Neuropsychopharmacology·Steven HaugbølGitte M Knudsen
May 24, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Robert B InnisRichard E Carson
Jun 5, 2007·Neurobiology of Aging·S G HasselbalchG M Knudsen
Sep 28, 2007·Psychopharmacology·René HurlemannAndreas Bauer
Feb 22, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·David ErritzoeBirte Y Glenthoj
May 31, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Florent C SureauRégine Trébossen
Oct 2, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Lisbeth MarnerSteen G Hasselbalch
Dec 17, 2008·Pharmacogenetics and Genomics·Eric J PetersSteven P Hamilton
Jan 1, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Vibe G FrokjaerGitte Moos Knudsen
Jan 6, 2010·The International Journal of Neuropsychopharmacology·Gonzalo LajeFrancis J McMahon
Mar 6, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·David ErritzoeGitte Knudsen
Nov 26, 2010·Journal of Alzheimer's Disease : JAD·Lisbeth MarnerSteen G Hasselbalch

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Citations

Dec 19, 2020·Scientific Reports·Vicki E MaltbyJeannette Lechner-Scott

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Methods Mentioned

BETA
blood draw
Genotyping
PCR

Software Mentioned

R
SPSS
Statistical Parametric Mapping ( SPM8 )
PVElab

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