Common integration sites for MMTV in viral induced mouse mammary tumors.

Journal of Mammary Gland Biology and Neoplasia
R Callahan, Gilbert H Smith

Abstract

The paradigm of mammary cancer induction by the mouse mammary tumor virus (MMTV) is used to illustrate the body of evidence that supports the hypothesis that mammary epithelial stem/progenitor cells represent targets for oncogenic transformation. It is argued that this is not a special case applicable only to MMTV-induced mammary cancer, because MMTV acts as an environmental mutagen producing random interruptions in the somatic DNA of infected cells by insertion of proviral DNA copies. In addition to disrupting the host genome, the proviral DNA also influences gene expression through its associated enhancer sequences over significant inter-genomic distances. Genes commonly affected by MMTV insertion in multiple individual tumors include, the Wnt, FGF, RSpo gene families as well as eIF3e and Notch4. All of these gene families are known to play essential roles in stem cell maintenance and behavior in a variety of organs. The MMTV-induced mutations accumulate in cells that are long-lived and possess the properties of stem cells, namely, self-renewal and the capacity to produce divergent epithelial progeny through asymmetric division. The evidence shows that epithelial cells with these properties are present in normal mammary gland...Continue Reading

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Citations

Jul 23, 2013·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Liane DeligdischBeatriz G T Pogo
Jul 8, 2009·Expert Review of Molecular Diagnostics·Pankaj TanejaKazushi Inoue
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Apr 2, 2016·ILAR Journal·Jaquelin P DudleySusan R Ross
Apr 13, 2018·Journal of Mammary Gland Biology and Neoplasia·Gilbert H Smith, Daniel Medina
Apr 18, 2017·Infectious Agents and Cancer·Thar Htet SanAkihiro Matsukawa
Jun 29, 2012·Molecular Cancer Research : MCR·Dafna FeldmanJacob Hochman
Jun 7, 2021·Cancer Letters·Angelina T ReguaHui-Wen Lo

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