Common mutations at the homocysteine metabolism pathway and pediatric stroke

Thrombosis Research
N AkarT Sipahi

Abstract

Heterozygosity and/or homozygosity for mutations at the genes of the enzymes involved in homocysteine metabolism may confer an increased risk for thrombosis by causing hyperhomocysteinemia. Although the mutations related to homocysteine metabolism possibly increase the risk of stroke, the data are conflicting and there are very few reports linking these defects to acute stroke in children. We aimed to study the role of these mutations in Turkish children with ischemic stroke. Forty-six patients having cerebral infarct were clinically diagnosed, and the infarction verified with magnetic resonance imaging of the brain was included in the study. All patients were below the age of 18 (10 months to 18 years). Sixty-eight controls, consecutively selected among healthy unrelated subjects from the same geographic area of Turkey without personal and family history of thrombosis, stroke or Behest's disease, were included. Genotyping for the common mutations was carried out by the methods described previously. There was no difference between the pediatric stroke patients and controls for the distribution of methylene tetrahydrofolate reductase (MTHFR) 677 C-T, MTHFR 1298 A-C, methylene tetrahydrofolate dehydrogenase (MTHFD) 1958 G-A and m...Continue Reading

References

Apr 25, 1991·The New England Journal of Medicine·R ClarkeI Graham
May 1, 1995·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·S GandrilleM Aiach
Jul 1, 1993·Journal of Child Neurology·I J Butler
Jul 1, 1993·Journal of Child Neurology·A R Riela, E S Roach
Mar 21, 1996·The New England Journal of Medicine·M den HeijerF R Rosendaal
Sep 26, 1996·The New England Journal of Medicine·M CattaneoP M Mannucci

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Citations

Nov 1, 2011·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Ekrem UnalMusa Karakukcu
Nov 25, 2003·Current Opinion in Pediatrics·Fenella J Kirkham
Sep 29, 2006·Journal of Pediatric Hematology/oncology·Nejat AkarSerap Tras Teber
Mar 23, 2005·Archives of Disease in Childhood·S HaywoodV Ganesan
Oct 25, 2012·Biochemia Medica·Renata Zadro, Désirée Coen Herak
Feb 6, 2008·Molecular Genetics and Metabolism·Martina HuemerDorothea Möslinger
Jun 28, 2005·Molecular Genetics and Metabolism·Valerie B O'LearyUNKNOWN Members of the Birth Defects Research Group
Mar 1, 2015·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Jiajia BiLi Yi
Dec 3, 2014·Jornal de pediatria·Vinicius M Torres, Vera A Saddi
Dec 3, 2014·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Anna BalcerzykIwona Żak
Aug 16, 2016·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Mert CalisGokhan Tuncbilek
Apr 29, 2004·American Journal of Hematology·Fahri UçarAlper Pakdemir
Aug 12, 2010·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Nurdan KöktürkNuman Ekim
Jan 1, 2016·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Désirée Coen HerakRenata Zadro
Dec 28, 2007·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Zuleyha YildizNejat Akar
Apr 19, 2018·Journal of Pediatric Hematology/oncology·Alper OzcanTurkan Patiroglu
Dec 7, 2002·Stroke; a Journal of Cerebral Circulation·James F Meschia
Nov 25, 2003·Stroke; a Journal of Cerebral Circulation·Karin KurnikUNKNOWN Childhood Stroke Study Group
Sep 9, 2010·European Journal of Clinical Nutrition·M HogeveenH J Blom
Mar 30, 2002·Current Opinion in Neurology·Eirini NestoridiEric F Grabowski
Jul 28, 2001·Nutrition Reviews·S Moyers, L B Bailey
Jun 21, 2003·The American Journal of Clinical Nutrition·Anne Lise Bjørke Monsen, Per Magne Ueland
Aug 27, 2005·Molecular Human Reproduction·Anne Parle-McDermottLawrence C Brody
Jun 7, 2007·Archives of Pathology & Laboratory Medicine·Aliyah Rahemtullah, Elizabeth M Van Cott
Nov 8, 2002·Archives of Pathology & Laboratory Medicine·Elizabeth M Van CottMartin H Prins

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