Common polymorphisms of Fibulin-5 and the risk of abdominal aortic aneurysm development

Vascular Medicine
Stephen A BadgerAnne E Hughes

Abstract

Fibulin-5 is a crucial protein in the connective tissue structure of the aortic wall. The purpose of this study was to determine if genetic variation within the Fibulin-5 gene was associated with abdominal aortic aneurysms (AAA). AAA patients, with disease-free controls, were recruited and a past medical history questionnaire completed. Three single nucleotide polymorphisms (SNPs) in the FBLN5 gene (rs2498834, rs2430366 and rs2254320) were genotyped. The two cohorts were compared and haplotype analysis performed. A total of 230 AAA cases and 278 controls were successfully genotyped. The mean age was 71.9 years (+/- 6.8). No difference between cases and controls was found in the distribution of alleles of FBLN5 SNPs rs2498834 (p = 0.47), rs2430366 (p = 0.45) or rs2254320 (p = 0.46). Haplotype analysis did not reveal any significant difference. In conclusion, genetic variation within FBLN5 is unlikely to play any role in the development of AAA.

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Citations

Oct 16, 2015·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·D T BradleyA E Hughes
Aug 18, 2020·Disease Models & Mechanisms·Joshua C PetersonMarco C DeRuiter
Jan 25, 2017·BioMed Research International·Ha Won Kim, Brian K Stansfield
Dec 15, 2010·Annals of Vascular Surgery·Irene HinterseherHelena Kuivaniemi

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