Common promoter C516T polymorphism in the ApoB gene is an independent predictor of carotid atherosclerotic disease in subjects presenting a broad range of plasma cholesterol levels

Arteriosclerosis, Thrombosis, and Vascular Biology
Andrei C SpositoJoëlle Thillet

Abstract

A common polymorphism in the promoter of the apolipoprotein B (apoB) gene, a C to T change at position -516, increases the transcription rate of apoB, resulting in elevated circulating levels of low-density lipoprotein (LDL) cholesterol. We tested the hypothesis that carriers of the -516T allele, who may display consistent elevation in plasma cholesterol over their lifetime, may present more extensive atherosclerotic disease than noncarriers. Genotyping of the apoB 516 C/T promoter polymorphism was performed in 326 subjects at low cardiovascular risk. Homozygotes for allele T displayed higher plasma levels of apoB and LDL than did heterozygotes. Furthermore, both homozygotes and heterozygotes for allele T exhibited higher plasma levels of apoB and LDL than did homozygotes for allele C (P<0.0001). In addition, homozygotes for allele T displayed higher carotid intima-media thickness (IMT) than subjects who were heterozygous. Moreover, both groups had higher carotid IMT than subjects of genotype -516C/C (P<0.001). Only age, high-density lipoprotein, and the presence of allele T were identified as independent predictors of the presence of carotid plaque. No association existed between the polymorphism and plasma concentrations of t...Continue Reading

References

Feb 4, 1993·The New England Journal of Medicine·M J KlagD M Levine
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Citations

Nov 3, 2007·Journal of Clinical Immunology·Bianca MarasiniMaria Luisa Biondi
Apr 28, 2006·Current Atherosclerosis Reports·Rebecca L Pollex, Robert Hegele
Oct 11, 2007·Pharmacogenomics·George V Z Dedoussis
Mar 21, 2007·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Pablo Perez-MartinezJose Lopez-Miranda
Sep 11, 2007·Atherosclerosis·Jinying ZhaoViola Vaccarino
Dec 17, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Chengliang ZhuJianguo Wu

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