Common properties of nuclear body protein SP100 and TIF1alpha chromatin factor: role of SUMO modification

Molecular and Cellular Biology
J S SeelerA Dejean

Abstract

The SP100 protein, together with PML, represents a major constituent of the PML-SP100 nuclear bodies (NBs). The function of these ubiquitous subnuclear structures, whose integrity is compromised in pathological situations such as acute promyelocytic leukemia (APL) or DNA virus infection, remains poorly understood. There is little evidence for the occurrence of actual physiological processes within NBs. The two NB proteins PML and SP100 are covalently modified by the ubiquitin-related SUMO-1 modifier, and recent work indicates that this modification is critical for the regulation of NB dynamics. In exploring the functional relationships between NBs and chromatin, we have shown previously that SP100 interacts with members of the HP1 family of nonhistone chromosomal proteins and that a variant SP100 cDNA encodes a high-mobility group (HMG1/2) protein. Here we report the isolation of a further cDNA, encoding the SP100C protein, that contains the PHD-bromodomain motif characteristic of chromatin proteins. We further show that TIF1alpha, a chromatin-associated factor with homology to both PML and SP100C, is also modified by SUMO-1. Finally, in vitro experiments indicate that SUMO modification of SP100 enhances the stability of SP100-...Continue Reading

References

Mar 1, 1991·The Journal of Cell Biology·C A Ascoli, G G Maul
Jun 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·T MikiS A Aaronson
Oct 1, 1995·The Journal of Cell Biology·T CarvalhoA Dejean
Feb 1, 1995·Trends in Biochemical Sciences·R AaslandA F Stewart
Oct 1, 1993·Molecular and Cellular Biology·K XieM Snyder
Aug 15, 1996·Genes & Development·J R FriedmanF J Rauscher
Nov 15, 1996·The Journal of Biological Chemistry·D B BlochK D Bloch
Dec 24, 1996·Proceedings of the National Academy of Sciences of the United States of America·S S KimJ V Bonventre
Apr 15, 1997·Proceedings of the National Academy of Sciences of the United States of America·J ZhuH de Thé
May 2, 1997·The Journal of Biological Chemistry·S ThénotV Cavaillès
May 1, 1997·Trends in Biochemical Sciences·F JeanmouginR Losson
Jun 6, 1998·Proceedings of the National Academy of Sciences of the United States of America·V J LaMorteR M Evans
Jun 24, 1998·Proceedings of the National Academy of Sciences of the United States of America·J S SeelerA Dejean
Jun 24, 1998·Proceedings of the National Academy of Sciences of the United States of America·N LehmingM Ptashne
Sep 12, 1998·Molecular Cell·J M DesterroR T Hay
Oct 22, 1998·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·G G Maul
May 14, 1999·Trends in Genetics : TIG·R J LinR M Evans
Jun 23, 1999·Current Opinion in Genetics & Development·J S Seeler, A Dejean
Jul 7, 1999·The EMBO Journal·A D HollenbachG Grosveld
Jul 15, 1999·Nature Structural Biology·F Winston, C D Allis
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·Y H KimY Kim
Nov 24, 1999·The EMBO Journal·M S RodriguezR T Hay
Nov 24, 1999·The EMBO Journal·M GostissaG Del Sal
Jan 29, 2000·The Journal of Cell Biology·F M BoisvertD P Bazett-Jones
Feb 8, 2000·The Journal of Biological Chemistry·V BhaskarA J Courey
Feb 12, 2000·Molecular and Cellular Biology·H LiJ D Chen
May 2, 2000·The Journal of Biological Chemistry·S MullerA Dejean
Aug 22, 2007·Trends in Cell Biology·P R Johnson, M Hochstrasser

❮ Previous
Next ❯

Citations

May 16, 2002·Journal of Cellular Physiology·Keun Il KimChin Ha Chung
Jun 24, 2004·Seminars in Cell & Developmental Biology·David W H GirdwoodRonald T Hay
Jun 24, 2004·Seminars in Cell & Developmental Biology·Felicity Z Watts
Jun 6, 2003·Advanced Drug Delivery Reviews·Joshua Z Gasiorowski, David A Dean
Dec 20, 2002·Journal of Structural Biology·Karien WiesmeijerRoeland W Dirks
May 16, 2006·Nature Cell Biology·Jung Hwa KimSung Hee Baek
Jun 7, 2011·Nature Structural & Molecular Biology·Aaron A GoodarziPenelope A Jeggo
Sep 21, 2004·Nature Structural & Molecular Biology·Andrea PichlerFrauke Melchior
Mar 15, 2013·Molecular Biology of the Cell·Alyshia NewhartSusan M Janicki
May 29, 2002·The EMBO Journal·Olivier KirshAnne Dejean
Mar 23, 2002·Molecular and Cellular Biology·Christine WasylykBohdan Wasylyk
Jun 11, 2004·Annual Review of Biochemistry·Erica S Johnson
Sep 24, 2005·The EMBO Journal·Paul D LingDonald B Bloch
Apr 8, 2011·The Journal of General Virology·Martina AdlerThomas Stamminger
Nov 2, 2014·The Journal of General Virology·Blair L Strang
Oct 11, 2008·Protein Expression and Purification·Huanting Liu, James H Naismith
Dec 18, 2007·Molecular Immunology·Tanja IlmarinenIsmo Ulmanen
Feb 25, 2005·Vitamins and Hormones·Philippe LefebvreBruno Lefebvre
Apr 6, 2005·Molecular Cell·Ronald T Hay
Oct 30, 2004·Current Opinion in Immunology·Maureen A Su, Mark S Anderson
Dec 1, 2009·Viruses·Nina Tavalai, Thomas Stamminger
Jan 17, 2002·Cell·Andrea PichlerFrauke Melchior
Mar 14, 2014·Journal of Virology·Julia BerscheminskiSabrina Schreiner
Apr 22, 2006·The EMBO Journal·Maya Capelson, Victor G Corces
May 12, 2007·The EMBO Journal·Puck KnipscheerTitia K Sixma
Mar 22, 2005·Journal of Cellular Biochemistry·Kent W WilcoxJerry L Taylor
Sep 25, 2003·Nature Reviews. Molecular Cell Biology·Jacob-S Seeler, Anne Dejean

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.