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Common SNPs explain a large proportion of the heritability for human height

Nature Genetics

Jun 22, 2010

Jian YangPeter M Visscher

Abstract

SNPs discovered by genome-wide association studies (GWASs) account for only a small fraction of the genetic variation of complex traits in human populations. Where is the remaining heritability? We estimated the proportion of variance for human height explained by 294,831 SNPs genotyped...read more

Mentioned in this Paper

Genome-Wide Association Study
Dysequilibrium Syndrome
Logistic Regression
Teens
Genetic Equilibrium
Linkage Disequilibrium
Simulation
Alleles
Genetic Predisposition to Disease
Single Nucleotide Polymorphism
38
3
2226
2
3
Paper Details
References
  • References28
  • Citations1380
123
  • References28
  • Citations1380
12345...

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Common SNPs explain a large proportion of the heritability for human height

Nature Genetics

Jun 22, 2010

Jian YangPeter M Visscher

PMID: 20562875

DOI: 10.1038/ng.608

Abstract

SNPs discovered by genome-wide association studies (GWASs) account for only a small fraction of the genetic variation of complex traits in human populations. Where is the remaining heritability? We estimated the proportion of variance for human height explained by 294,831 SNPs genotyped...read more

Mentioned in this Paper

Genome-Wide Association Study
Dysequilibrium Syndrome
Logistic Regression
Teens
Genetic Equilibrium
Linkage Disequilibrium
Simulation
Alleles
Genetic Predisposition to Disease
Single Nucleotide Polymorphism
38
3
2226
2
3

Trending Feeds

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Related Papers

American Journal of Human Genetics

GCTA: a tool for genome-wide complex trait analysis

American Journal of Human GeneticsDecember 21, 2010
Jian YangPeter M Visscher
Paper Details
References
  • References28
  • Citations1380
123
  • References28
  • Citations1380
12345...
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