Common SNPs explain a large proportion of the heritability for human height

Nature Genetics
Jian YangPeter M Visscher

Abstract

SNPs discovered by genome-wide association studies (GWASs) account for only a small fraction of the genetic variation of complex traits in human populations. Where is the remaining heritability? We estimated the proportion of variance for human height explained by 294,831 SNPs genotyped on 3,925 unrelated individuals using a linear model analysis, and validated the estimation method with simulations based on the observed genotype data. We show that 45% of variance can be explained by considering all SNPs simultaneously. Thus, most of the heritability is not missing but has not previously been detected because the individual effects are too small to pass stringent significance tests. We provide evidence that the remaining heritability is due to incomplete linkage disequilibrium between causal variants and genotyped SNPs, exacerbated by causal variants having lower minor allele frequency than the SNPs explored to date.

References

Mar 1, 1972·Behavior Genetics·J K Haseman, R C Elston
Jun 19, 2001·American Journal of Human Genetics·J K Pritchard
Nov 20, 2003·Twin Research : the Official Journal of the International Society for Twin Studies·Karri SilventoinenJaakko Kaprio
Sep 6, 2007·Genome Research·Naomi R WrayPeter M Visscher
Mar 6, 2008·Nature Reviews. Genetics·Peter M VisscherNaomi R Wray
Apr 9, 2008·Nature Genetics·Daniel F GudbjartssonKari Stefansson
Apr 9, 2008·Nature Genetics·Michael N WeedonTimothy M Frayling
Apr 30, 2008·Nature Genetics·Peter M Visscher
Oct 18, 2008·Nature Reviews. Genetics·Frank JohannesRitsert C Jansen
Mar 7, 2009·Genome Research·Brian P McEvoyPeter M Visscher
Mar 17, 2009·Genetics, Selection, Evolution : GSE·Theo H E MeuwissenJohn A Woolliams
Mar 19, 2009·Nature Reviews. Genetics·Kelly A FrazerEric J Topol
May 7, 2009·Genetics·Montgomery Slatkin
May 19, 2009·Nature Reviews. Genetics·Michael E Goddard, Ben J Hayes
May 29, 2009·Proceedings of the National Academy of Sciences of the United States of America·Lucia A HindorffTeri A Manolio
Jun 27, 2009·PLoS Genetics·Frank JohannesVincent Colot
Oct 9, 2009·Nature·Teri A ManolioPeter M Visscher

❮ Previous
Next ❯

Citations

Jul 9, 2011·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Nanye LongKent A Weigel
Aug 7, 2012·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Mark A NewellJean-Luc Jannink
Oct 12, 2012·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Tobias WürschumJochen C Reif
Jan 25, 2012·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Robert K Wayne, Bridgett M vonHoldt
Nov 26, 2010·Human Genetics·Chee Seng KuYudi Pawitan
Feb 23, 2011·Human Genetics·Guillaume Lettre
Apr 21, 2011·Human Genetics·Angus Clarke, Katie Thirlaway
Mar 13, 2012·Human Genetics·Isabel MendizabalDavid Comas
Jul 24, 2012·Human Genetics·Noah Zaitlen, Peter Kraft
Aug 18, 2012·Human Genetics·Andreas Ziegler, Yan V Sun
Oct 12, 2012·Human Genetics·Sharon R Browning, Brian L Browning
Oct 28, 2010·Behavior Genetics·Sophia J DochertyRobert Plomin
Apr 24, 2013·Behavior Genetics·Maciej TrzaskowskiRobert Plomin
Aug 15, 2013·Behavior Genetics·Matt McGueWilliam G Iacono
Jul 28, 2012·Journal of Abnormal Child Psychology·Heather A Priess-Groben, Janet Shibley Hyde
Jul 13, 2013·Current Osteoporosis Reports·Cheryl L Ackert-Bicknell, David Karasik
Feb 26, 2013·Current Psychiatry Reports·Matthew Ezewudo, Michael E Zwick
Dec 15, 2012·International Journal of Hematology·Kevin Y UrayamaShuki Mizutani
Jul 16, 2013·Theoretical Population Biology·Serge Sverdlov, Elizabeth A Thompson
Aug 27, 2013·Theoretical Population Biology·Montgomery Slatkin
Apr 2, 2013·Trends in Ecology & Evolution·Etienne Danchin
Mar 25, 2011·Genetics Research·Jinhee Kim, Greg Gibson
Mar 25, 2011·Genetics Research·Peter M VisscherJian Yang
Mar 25, 2011·Genetics Research·Nengjun Yi
Mar 25, 2011·Genetics Research·Michael E GoddardTheo H E Meuwissen
Mar 25, 2011·Genetics Research·B S Weir, C C Laurie
Sep 7, 2012·Genetics Research·Kathryn E KemperMichael E Goddard
Feb 28, 2013·Genetics Research·Jing ZhaoGreg Gibson
Oct 16, 2012·Development and Psychopathology·Scott I VriezeMatt McGue
Oct 16, 2012·Development and Psychopathology·Colin G DeYoung, Rachel Clark
Oct 17, 2013·Animal : an International Journal of Animal Bioscience·J E PryceB J Hayes
Aug 27, 2010·Nature·David Cyranoski
Mar 17, 2011·European Journal of Human Genetics : EJHG·Jian YangUNKNOWN GIANT Consortium
Apr 12, 2012·European Journal of Human Genetics : EJHG·Erik A EhliGareth E Davies
Mar 27, 2013·International Journal of Obesity : Journal of the International Association for the Study of Obesity·C H LlewellynJ Wardle
Dec 22, 2010·Molecular Psychiatry·M H M de MoorD I Boomsma
Apr 13, 2011·Molecular Psychiatry·D M RuderferS M Purcell

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Related Papers

American Journal of Human Genetics
Jian YangPeter M Visscher
Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies
Peter M VisscherMichael E Goddard
© 2021 Meta ULC. All rights reserved