Common traits between the beige fat-inducing stimuli

Current Opinion in Cell Biology
Ozren StojanovićMirko Trajkovski

Abstract

Adipose tissues play an essential role in regulating the metabolic homeostasis and can be found in almost all parts of the body. Excessive adiposity leads to obesity and can contribute to metabolic and other disorders. Adipocytes show remarkable plasticity in their function, which can be pushed toward energy storage, or energy expenditure-a `browning' of fat. Browning is controlled by the cellular milieu of the adipose tissue, with sympathetic innervation and by immune responses as key integrators of the signals that promote browning. Here, we describe the latest contributions to our understanding of how different metabolic stimuli can shape the adipocyte function. We especially focus on the role of the gut microbiota and the negative energy balance in regulating the browning.

Citations

Jan 14, 2020·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Martin Jastroch, Frank Seebacher
Jan 14, 2020·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Jorge Cubo, Adam K Huttenlocker
Dec 5, 2019·International Journal of Molecular Sciences·Silvia Lorente-CebriánHeriberto Castro
Sep 8, 2021·Nature Communications·Adela UrisarriMiguel López

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