PMID: 7542578Jul 1, 1995Paper

Common variable immunodeficiency (CVID) and MxA-protein expression in blood leucocytes

Clinical and Experimental Immunology
J A RumpH H Peter

Abstract

The underlying immunopathogenic mechanism of CVID has been suspected to involve a chronic viral infection or an autoimmune condition. However, formal proof of viral infection is lacking. Measurement of MxA-protein in leucocyte lysates is a sensitive test for evaluating the activation of the host's interferon system. Both viral infections and autoimmune diseases such as systemic lupus erythematosus (SLE) strongly induce MxA-protein in peripheral leucocytes. We therefore examined 15 patients with longlasting hypogammaglobulinaemia for MxA-protein induction in vivo: 13 patients suffered from CVID, one from hyper-IgM syndrome, and one patient had chronic B lymphocytic leukaemia associated with immunoglobulin deficiency and chronic papilloma virus infection (condylomata accuminata). Only the latter patient exhibited a strong MxA-protein expression; two CVID patients were borderline positive, and the remaining 12 patients including the hyper-IgM syndrome were MxA-protein-negative. There was no relationship between MxA expression and low CD4/CD8 ratios or increased CD8/CD57+ T cell counts, although both conditions are often observed in CVID as well as in chronic viral infections. When exposed in vitro to interferon-alpha (IFN-alpha), ...Continue Reading

References

Oct 1, 1992·Clinical and Experimental Immunology·E BaumertH H Peter
Apr 1, 1992·Journal of Interferon Research·H TowbinM A Horisberger
Oct 1, 1991·Clinical Immunology and Immunopathology·Y LebranchuP Bardos
Jun 1, 1991·American Journal of Hematology·C Cunningham-RundlesR S Chaganti
Jan 1, 1991·Clinical and Experimental Immunology·D E NilssenL A Hanson
Sep 1, 1990·European Journal of Immunology·P von WussowH Deicher
Jun 1, 1989·Immunology Today·G P Spickett, J Farrant
Jan 1, 1989·Journal of Clinical Immunology·C Cunningham-Rundles
Feb 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·M FarringtonH D Ochs
Feb 1, 1994·Clinical and Experimental Immunology·E W HerbstH H Peter

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Citations

Oct 27, 2006·Pediatric Hematology and Oncology·Minna M KoskenvuoMika J Mäkelä
Apr 23, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·G AntonelliF Dianzani
Jul 2, 2008·Parkinsonism & Related Disorders·N KawaguchiT Hattori

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