Common variable immunodeficiency is associated with defective functions of dendritic cells.

Blood
Jagadeesh BayryS V Kaveri

Abstract

Common variable immunodeficiency (CVID) is characterized by hypogammaglobulinemia and defects in T-cell functions that could be primary or secondary. We addressed whether CVID is associated with impairment in the dendritic cell (DC) compartment, as DCs play a central role in the development of adaptive immunity. We demonstrate that DCs from CVID patients display severely perturbed differentiation, maturation, and function, and express markedly reduced levels of the costimulatory molecules that are critical for T-cell stimulation. Patients' DCs induced weak proliferation of allogeneic T cells and produced significantly low amounts of interleukin-12 (IL-12) upon CD40 signaling. Multiple defects in the immune system, including malfunctioning of DCs, appear to be prominent features of CVID patients. Impairment in both the innate and adaptive compartments of the immune system may thus cumulatively account for the inability of CVID patients to eradicate pathogens through conventional immune pathways, thus resulting in an increased risk for recurrent bacterial infections.

Citations

Sep 18, 2010·Inflammatory Bowel Diseases·Daniel J B MarksStuart L Bloom
May 2, 2009·Clinical and Experimental Medicine·Asghar AghamohammadiAli Akbar Amirzargar
Mar 14, 2007·Journal of Clinical Immunology·Vir-Singh NegiSrini V Kaveri
Oct 6, 2007·Immunologic Research·Charlotte Cunningham-Rundles, Adina Kay Knight
Oct 18, 2006·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Yew Kuang ChengCatherine R Weiler
Oct 7, 2005·Arthritis Research & Therapy·Jean-François ViallardPatrick Blanco
Oct 10, 2012·Arthritis Research & Therapy·Ulrich SalzerHans Hartmut Peter
Feb 5, 2009·Pediatric Research·Francisco A Bonilla, Raif S Geha
Mar 1, 2012·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Tomohiro Morio
Sep 17, 2014·The Journal of Experimental Medicine·Matthieu PerreauGiuseppe Pantaleo
Nov 3, 2005·Current Opinion in Allergy and Clinical Immunology·Sigune Goldacker, Klaus Warnatz
Jul 24, 2013·Current Opinion in Allergy and Clinical Immunology·Valérie Gouilleux-GruartAlain Fischer
Dec 7, 2013·Immunopharmacology and Immunotoxicology·Jihong QianTongxin Chen
Jul 1, 2005·Expert Review of Clinical Immunology·Jagadeesh BayrySrini V Kaveri
Sep 17, 2014·Expert Review of Clinical Immunology·Asghar AghamohammadiNima Rezaei
Oct 17, 2013·Expert Review of Clinical Immunology·Yashwant Kumar, Alka Bhatia
Dec 15, 2015·Expert Review of Clinical Immunology·Laleh SharifiAsghar Aghamohammadi
Sep 6, 2011·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Sander van AssenMarc Bijl
Jan 26, 2010·Human Immunology·Nima RezaeiRobert C Read
Sep 1, 2009·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Omür Ardeniz, Charlotte Cunningham-Rundles
Dec 19, 2006·Allergologia et immunopathologia·A Blanco-QuirósE Arranz-Sanz
Oct 18, 2008·Trends in Immunology·Thanyalak Tha-InJaap Kwekkeboom
Oct 23, 2008·Immunology and Allergy Clinics of North America·Patrick F K YongBodo Grimbacher
Jul 16, 2008·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Silvia Sánchez-RamónCharlotte Cunningham-Rundles
Apr 22, 2008·Immunology and Allergy Clinics of North America·Patrick F K YongRonnie Chee
Jun 19, 2008·Autoimmunity Reviews·Janakiraman VaniSrini V Kaveri
Jun 19, 2008·Autoimmunity Reviews·Sri-Ramulu ElluruJagadeesh Bayry
Feb 26, 2008·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Patrick F K YongMohammad A A Ibrahim
Sep 11, 2007·The Journal of Allergy and Clinical Immunology·Rosa M AspalterHermann M Wolf
May 15, 2007·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·Stéphanie Graff-DuboisSrini V Kaveri
May 1, 2007·Current Opinion in Genetics & Development·Alejandro A SchäfferBodo Grimbacher
Jun 21, 2005·Scandinavian Journal of Immunology·L Ohm-LaursenT Barington
May 12, 2009·Immunological Reviews·Patrick F K YongBodo Grimbacher
Aug 16, 2006·Clinical and Experimental Immunology·T H Scott-TaylorA D Webster
Oct 4, 2007·Annals of the New York Academy of Sciences·Sophie SibérilSrini V Kaveri
Oct 13, 2006·Clinical and Experimental Immunology·M RaeiszadehA D Webster
Apr 16, 2011·Clinical and Experimental Immunology·S V KaveriJ Bayry

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]
M NourizadehJ Hadjati
Trends in Molecular Medicine
Jagadeesh BayryS V Kaveri
Proceedings of the National Academy of Sciences of the United States of America
Jagadeesh BayryS V Kaveri
© 2022 Meta ULC. All rights reserved