Common variants in IL17F gene contributed to the risk of hip osteoarthritis susceptibility in Han Chinese population.

International Journal of Rheumatic Diseases
Tianyun ZhaoJibin Liu

Abstract

The prevalence of hip and knee osteoarthritis (OA) varies by ethnicity, suggesting genetic heterogeneity in populations and predilection sites. Given the unknown mechanism of IL17F gene in the etiology of OA, it is necessary to examine the potential shared susceptibility of IL17F gene between knee OA and hip OA (HOA). This study aimed to evaluate the association of the IL17F gene and susceptibility to HOA in a Han Chinese population. A total of 2650 study subjects, comprising 796 HOA patients and 1854 controls, were recruited into the present study. Seven tag single nucleotide polymorphisms (SNPs) were selected for genotyping. Single marker-based genetic association analyses were conducted at both the genotypic and allelic levels. χ2 statistics were calculated for statistical testing, and odds ratios were obtained to estimate the effects of genotypes and alleles for each SNP. The SNP rs763780 was identified to be significantly associated with the risk of HOA at both genotypic (χ2  = 12.45, P = .002) and allelic levels (χ2  = 11.83, P = .0006). A linkage disequilibrium (LD) block comprised of 3 SNPs (rs12201582-rs12203736-rs722323) was also significantly associated with the risk of HOA. In addition, rs2294835 was identified to b...Continue Reading

References

Nov 20, 1987·The American Journal of Medicine·R W Moskowitz
Sep 29, 2001·The Journal of the American Academy of Orthopaedic Surgeons·F T Hoaglund, L S Steinbach
May 25, 2002·Science·Stacey B GabrielDavid Altshuler
Aug 13, 2002·European Journal of Human Genetics : EJHG·John LoughlinKay Chapman
Aug 7, 2004·Bioinformatics·J C BarrettM J Daly
Jul 11, 2009·Seminars in Arthritis and Rheumatism·Gabriel Herrero-BeaumontSergio A Jimenez
Apr 1, 2010·Nature Methods·Ivan A AdzhubeiShamil R Sunyaev
Dec 7, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Federico InnocentiMark J Ratain
Jun 13, 2012·Nucleic Acids Research·Ngak-Leng SimPauline C Ng
Mar 8, 2013·The Journal of Bone and Joint Surgery. American Volume·Franklin T Hoaglund
Feb 28, 2015·GigaScience·Christopher C ChangJames J Lee
May 5, 2017·International Journal of Cancer. Journal International Du Cancer·Hongwei TangDonghui Li
Dec 2, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Goran VrgocZdravko Jotanovic
Oct 3, 2018·Alcoholism, Clinical and Experimental Research·Alexis C EdwardsMarc A Schuckit
Dec 31, 2018·Blood Cells, Molecules & Diseases·Fetnat Mahmoud TolbaShereen Abdel-Sadek Mohamed
May 2, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·RandiK EftedalZlatko Dembic

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Citations

Jul 3, 2021·Journal of Personalized Medicine·Janisleya Silva Ferreira NevesAna Maria Sell

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