Common variants of the G protein-coupled receptor type 4 are associated with human essential hypertension and predict the blood pressure response to angiotensin receptor blockade

The Pharmacogenomics Journal
Hironobu SanadaPedro A Jose

Abstract

Non-synonymous GRK4 variants, R65L, A142V and A486V, are associated with essential hypertension in diverse populations. This study replicated the association of GRK4 variants, including GRK4(142V), with human essential hypertension in a Japanese population (n=588; hypertensive, n=486 normotensive controls) and determined whether the presence of GRK4 variants predicted the blood pressure (BP) response to angiotensin receptor blockers (ARBs) in patients with essential hypertension. We analyzed 829 patients and compared the response to ARBs between individuals with no GRK4 variants (n=136) and those with variants at one or any of the three loci (n=693). Carriers of hGRK4(142V) had a greater decrease in systolic BP in response to ARBs than non-carrier hypertensive patients. By contrast, those with variants only at GRK4(486V) were less likely to achieve the BP goal in response to an ARB than those with no variants. These studies showed for the first time the association between GRK4(142V) and a larger decrease in BP with ARBs in hypertensive patients.

References

Mar 15, 1996·The Journal of Biological Chemistry·R T PremontR J Lefkowitz
Mar 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Robin A FelderPedro A Jose
Aug 8, 2002·Kidney International·Hidetsuna WatanabeRobin A Felder
Dec 21, 2002·Science·Anne M GlazierTimothy J Aitman
Jan 18, 2005·Lancet·Patricia M KearneyJiang He
Mar 31, 2005·American Journal of Physiology. Renal Physiology·Meghna Trivedi, Mustafa F Lokhandwala
Apr 19, 2005·American Journal of Human Genetics·Jacqueline K Wittke-ThompsonNancy J Cox
May 26, 2005·Cardiovascular Research·Kirsten LeineweberOtto-Erich Brodde
Jun 9, 2005·Journal of Hypertension·Philip B Mellen, David M Herrington
Dec 17, 2005·Vascular Pharmacology·Donna K ArnettStephen P Glasser
Jan 28, 2006·Clinical Chemistry·Hironobu SanadaRobin A Felder
Jun 7, 2006·Hypertension·Johann Bauersachs, Daniela Fraccarollo
Jan 30, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Zheng WangPedro A Jose
Jan 31, 2007·Naunyn-Schmiedeberg's Archives of Pharmacology·Dieter RosskopfRafael Schäfers
Oct 12, 2007·Kidney International·S ReungjuiR J Johnson
May 14, 2008·Genetic Epidemiology·Kelli K RyckmanScott M Williams
Oct 30, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Junichi YatabePedro A Jose
Mar 6, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Toshio OgiharaUNKNOWN COLM study investigators
Apr 3, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Seiichi MatsuoUNKNOWN Collaborators developing the Japanese equation for estimated GFR
Feb 16, 2010·Biochimica Et Biophysica Acta·Pedro A JoseRobin A Felder
Apr 23, 2010·Journal of the American Society of Hypertension : JASH·Stephen B Harrap
May 27, 2010·JAMA : the Journal of the American Medical Association·Brent M EganR Neal Axon
Sep 30, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Yumiko HiuraNaoharu Iwai
Jan 26, 2011·Circulation·Paul A HeidenreichUNKNOWN Council on Cardiovascular Surgery and Anesthesia, and Interdisciplinary Council on Quality of Care and Outcomes Research
Apr 15, 2011·Annals of Human Genetics·Scott M Williams, Jonathan L Haines
May 5, 2011·JAMA : the Journal of the American Medical Association·Katarzyna Stolarz-SkrzypekUNKNOWN European Project on Genes in Hypertension (EPOGH) Investigators
Sep 17, 2011·Circulation Research·Dan M RodenRussell A Wilke
Nov 24, 2011·JAMA : the Journal of the American Medical Association·Martin J O'DonnellRoland E Schmieder
Nov 30, 2011·Current Opinion in Nephrology and Hypertension·Raymond C Harris
Dec 15, 2012·Circulation·Alan S GoUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Jan 10, 2013·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Kazuo HayakawaUNKNOWN Osaka Twin Research Group
Apr 6, 2013·BMJ : British Medical Journal·Nancy J AburtoJoerg J Meerpohl

❮ Previous
Next ❯

Citations

Jun 9, 2017·Pharmacogenomics·Hazel Xiaohui AngMichael D Winther
Jul 9, 2016·Journal of the American Heart Association·Jian YangChunyu Zeng
Apr 6, 2016·Hypertension·Pedro A JoseGilbert M Eisner
Nov 26, 2015·Nature Reviews. Nephrology·Rhonda M Cooper-DeHoff, Julie A Johnson
Mar 8, 2019·Perspectives on Psychological Science : a Journal of the Association for Psychological Science·Christopher C ConwayNicholas R Eaton
Aug 7, 2017·Current Hypertension Reports·Andrew C TiuVan Anthony M Villar
Jul 21, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yang YangYukai Liu
Jul 3, 2015·The Journal of Biological Chemistry·Samantha J AllenKevin J Lumb
Dec 2, 2020·International Journal of Molecular Sciences·Victor J MartinezAndrew C Tiu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.