Common variation in the lipoprotein lipase gene: effects on plasma lipids and risk of atherosclerosis

Atherosclerosis
R FisherP Talmud

Abstract

The importance of the enzyme lipoprotein lipase (LPL) in the development of dyslipidaemia and atherosclerosis is increasingly recognised. Variations in the LPL gene which are common in the general population have been shown to be associated with alterations in plasma lipids. D9N and N291S both occur at carrier frequencies of up to about 5% and have been associated with increased plasma triacylglycerol and decreased high density lipoprotein cholesterol concentrations, effects which seem to be magnified in more obese individuals. S447X carrier frequency is approximately 20%, but unlike carriers of N9 or S291, X447 carriers appear to have a more favourable lipid profile. A transition within the LPL promoter at position-93 may lead to increased LPL activity and have a beneficial effect on plasma lipids. Greater knowledge of the underlying mechanisms of these variations within the LPL gene may be of considerable importance in understanding genetic predisposition to atherosclerosis and heart disease.

References

Oct 1, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·S P BabirakJ D Brunzell
Jan 3, 1992·Biochimica Et Biophysica Acta·C S WangW J McConathy
Sep 1, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·T PollareH Lithell
Sep 21, 1991·BMJ : British Medical Journal·J Garrow
Mar 1, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·J de GraafA F Stalenhoef
Feb 22, 1990·Nature·F K WinklerW Hunziker
Jul 1, 1990·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·M A AustinR M Krauss
Oct 1, 1989·European Journal of Clinical Investigation·J KobayashiS Yoshida
Nov 11, 1989·Nucleic Acids Research·R A HegeleR White
Dec 11, 1989·Nucleic Acids Research·R A HegeleR White
May 16, 1989·Biochemistry·S S Deeb, R L Peng
Aug 25, 1987·Nucleic Acids Research·C HeinzmannA J Lusis
Sep 25, 1987·Nucleic Acids Research·K L FisherR M Lawn
Mar 25, 1988·Nucleic Acids Research·H FunkeG Assmann
Dec 23, 1988·Nucleic Acids Research·S LiJ Stocks
May 1, 1988·Metabolism: Clinical and Experimental·R SorvaE A Nikkilä
Aug 1, 1986·American Heart Journal·W P Castelli
Jan 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·A SnidermanP O Kwiterovich
May 1, 1995·Nature Genetics·H Funke, G Assmann
Apr 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·A F StalenhoefR Zechner
May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·W S YangS S Deeb
Jul 1, 1994·Metabolism: Clinical and Experimental·T R PodlP D Thompson
Aug 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·E GagnéM R Hayden
Jan 1, 1994·The Clinical Investigator·M SeedS E Humphries
Jun 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·D N NevinS S Deeb
Jan 1, 1993·Human Mutation·A L Beaudet, L C Tsui

❮ Previous
Next ❯

Citations

Apr 26, 2008·Biochemical Genetics·Azim NejatizadehM A Qadar Pasha
Mar 31, 2011·Biochemical Genetics·Rajneesh TripathiVenkataraman Ramesh
Apr 5, 2001·Current Atherosclerosis Reports·P J Talmud
Dec 21, 2000·Current Atherosclerosis Reports·S Gehrisch
Mar 15, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Shui-Ping ZhaoShai Nie
Aug 21, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Katia A AlmeidaRaul C Maranhão
Jun 8, 2002·Atherosclerosis·Anke Hilse Maitland-van der ZeeAnthonius de Boer
Sep 6, 2003·Atherosclerosis·Y Stein, O Stein
Nov 24, 2004·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·I FelicielloG Chinali
Sep 13, 2001·Journal of Molecular Graphics & Modelling·H RazzaghiM I Kamboh
Aug 21, 2007·The British Journal of Nutrition·José Lopez-MirandaDenis Lairon
Apr 16, 2009·European Journal of Human Genetics : EJHG·Mandy van HoekEric J G Sijbrands
Mar 23, 2006·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A Q HuangL M Lee
Jan 12, 2008·Journal of the American College of Nutrition·Bernard HerbethSophie Visvikis-Siest
Jan 10, 2013·Human Reproduction Update·A J BuurmaH J Baelde
Aug 17, 2001·Current Opinion in Lipidology·P J Talmud, S E Humphries
Dec 23, 2003·Diabetes, Obesity & Metabolism·Philippa J Talmud, Jeffrey W Stephens
Jul 11, 2006·Lipids in Health and Disease·Shu-Fen WungBradley E Aouizerat
Nov 3, 2010·Journal of Lipid Research·Christopher T JohansenRobert A Hegele
Jul 16, 2004·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Biao LiRunsheng Chen
Nov 7, 1998·Clinical Chemistry and Laboratory Medicine : CCLM·C P Pang
May 16, 2003·Clinical Chemistry and Laboratory Medicine : CCLM·Goran FerencakAna Stavljenić Rukavina
Oct 29, 2003·Clinical Chemistry and Laboratory Medicine : CCLM·Domingos L S RiosMara H Hutz
Jun 17, 2006·Clinical Chemistry and Laboratory Medicine : CCLM·Despoina M ChoumerianouGeorge V Z Dedoussis
May 9, 2007·Clinical Chemistry and Laboratory Medicine : CCLM·Carolina de Oliveira GigekMarília de Arruda Cardoso Smith
Mar 20, 2009·Canadian Journal of Physiology and Pharmacology·Amit R RahalkarTisha Joy

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.